4-Methoxycinnamaldehyde

Modify Date: 2026-07-30 19:24:40

4-Methoxycinnamaldehyde Structure
4-Methoxycinnamaldehyde structure
Common Name 4-Methoxycinnamaldehyde
CAS Number 1963-36-6 Molecular Weight 162.185
Density 1.1±0.1 g/cm3 Boiling Point 308.7±17.0 °C at 760 mmHg
Molecular Formula C10H10O2 Melting Point 55-60ºC(lit.)
MSDS N/A Flash Point 146.5±14.5 °C

 Use of 4-Methoxycinnamaldehyde


4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC50 of 0.055 μg/mL[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name p-Methoxycinnamic aldehyde
Synonym More Synonyms

 4-Methoxycinnamaldehyde Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description 4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC50 of 0.055 μg/mL[1].
Related Catalog
References

[1]. Kuo Chih Wang, et al. 4-Methoxycinnamaldehyde inhibited human respiratory syncytial virus in a human larynx carcinoma cell line. Phytomedicine. 2009 Sep;16(9):882-6.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.1±0.1 g/cm3
Boiling Point 308.7±17.0 °C at 760 mmHg
Melting Point 55-60ºC(lit.)
Molecular Formula C10H10O2
Molecular Weight 162.185
Flash Point 146.5±14.5 °C
Exact Mass 162.068085
PSA 26.30000
LogP 2.07
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.559

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.


Section I.Chemical Product and Company Identification
Chemical Name 4-Methoxycinnamaldehyde
Portland OR
Synonym3-(4-methoxyphenyl)acrylaldehyde
Chemical FormulaCH3OC6H4CH:CHCHO
CAS Number1963-36-6

Section II.Composition and Information on Ingredients
Chemical NameCAS Number Percent (%)TLV/PELToxicology Data
4-Methoxycinnamaldehyde1963-36-6Min. 97.0 Not available.Not available.
(GC)

Section III. Hazards Identification
Acute Health EffectsIrritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening,
or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when
handling this compound.
CARCINOGENIC EFFECTS : Not available.
Chronic Health Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
Toxicity to the reproductive system: Not available.
There is no known effect from chronic exposure to this product. Repeated or prolonged exposure to this compound is
not known to aggravate existing medical conditions.

Section IV.First Aid Measures
Eye ContactCheck for and remove any contact lenses. DO NOT use an eye ointment. Flush eyes with running water for a minimum
of 15 minutes, occasionally lifting the upper and lower eyelids. Seek medical attention. Treat symptomatically and
supportively.
Skin ContactIf the chemical gets spilled on a clothed portion of the body, remove the contaminated clothes as quickly as possible,
protecting your own hands and body. Place the victim under a deluge shower. If the chemical touches the victim's
exposed skin, such as the hands: Gently and thoroughly wash the contaminated skin with running water and non-abrasive
soap. Be particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with an emollient. Seek
medical attention. Treat symptomatically and supportively. Wash any contaminated clothing before reusing.
InhalationIf the victim is not breathing, perform artificial respiration. Loosen tight clothing such as a collar, tie, belt or waistband. If
breathing is difficult, oxygen can be administered. Seek medical attention. Treat symptomatically and supportively.
Remove dentures if any. Have conscious person drink several glasses of water or milk. INDUCE VOMITING by sticking
Ingestion
finger in throat. Lower the head so that the vomit will not reenter the mouth and throat. NEVER give an unconscious
person anything to ingest. Seek medical attention. Treat symptomatically and supportively.

Section V. Fire and Explosion Data
Not available.
FlammabilityCombustible.Auto-Ignition
Flammable Limits
Flash PointsNot available.
Not available.
Combustion ProductsThese products are carbon oxides (CO, CO 2).
Fire Hazards
No specific information is available regarding the flammability of this compound in the presence of various materials.
Explosion HazardsRisks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
No additional information is available regarding the risks of explosion.
Fire Fighting Media
SMALL FIRE: Use DRY chemicals, CO 2, water spray or foam.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Continued on Next Page
4-Methoxycinnamaldehyde

Section VI.Accidental Release Measures
Spill CleanupIn case of a spill and/or a leak, always shut off any sources of ignition, ventilate the area, and exercise caution. Use a
Instructionsshovel to put the material into a convenient waste disposal container. Finish cleaning the spill by rinsing any
contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on
disposal.

Section VII. Handling and Storage
Handling and StorageIRRITANT. Keep away from heat and sources of ignition. Mechanical exhaust required. When not in use, tightly seal the
container and store in a dry, cool place. Avoid excessive heat and light. DO NOT ingest. DO NOT breathe dust. In case
Information
of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the
container or the label. Treat symptomatically and supportively. Avoid contact with skin and eyes.
Always store away from incompatible compounds such as oxidizing agents.

Section VIII. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSplash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling
this product.
Exposure LimitsNot available.

Section IX. Physical and Chemical Properties
Solubility
Physical state @ 20°CSolid. (Powder.)Not available.
Not available.
Specific Gravity
Molecular Weight162.19Partition CoefficientNot available.
Boiling PointNot available.Vapor PressureNot available.
Melting Point58°C (136.4°F)Vapor DensityNot available.
Not available.VolatilityNot available.
Refractive Index
Critical TemperatureOdorNot available.
------------
ViscosityNot available.TasteNot available.

Section X.Stability and Reactivity Data
Stability
This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of Instability
Air and light sensitive.
Incompatibilities
Highly reactive with oxidizing agents.

Section XI. Toxicological Information
RTECS NumberNot available.
Routes of ExposureIngestion. Inhalation. Eye contact. Skin contact.
Not available.
Toxicity Data
No additional remark.
Chronic Toxic EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
Toxicity to the reproductive system: Not available.
There is no known effect from chronic exposure to this product. Repeated or prolonged exposure to this compound is not
known to aggravate existing medical conditions.
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
Acute Toxic Effects
eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening,
or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when
handling this compound.
Continued on Next Page
4-Methoxycinnamaldehyde

Section XII.Ecological Information
EcotoxicityNot available.
Environmental FateNot available.

Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local or regional authorities. You may be able to dissolve or mix material with
Waste Disposal
a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state, and local regulations when disposing of this substance.

Section XIV. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
PIN NumberNot available.
Proper Shipping Name
Not available.
Packing Group (PG)Not available.
DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is ON the Toxic Substances Control Act (TSCA) list.
(EPA)
WHMIS Classification
WHMIS CLASS D-2B: Material causing other toxic effects (TOXIC).
(Canada)
EINECS Number (EEC) Not available.
EEC Risk StatementsR36/38- Irritating to eyes and skin.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36
WGK Germany 3
HS Code 2912499000

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2912499000
Summary 2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 4-MethoxycinnamaldehydeBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Inhibition of LuxR quorum sensing system in Vibrio harveyi BB120 assessed as inhibiti...
Source: ChEMBL
Target: HTH-type transcriptional regulator LuxR
External Id: CHEMBL5265248
Name: Toxicity in rat
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1017319
Name: Antimicrobial activity against Trichophyton rubrum MTCC 296 assessed as growth inhibi...
Source: ChEMBL
Target: Trichophyton rubrum
External Id: CHEMBL3075363
Name: Inhibition of cAMP phosphodiesterase at 0.05 mM
Source: ChEMBL
Target: N/A
External Id: CHEMBL1017318
Name: Herbicidal activity against velvetleaf assessed as seed germination at 1 mM after 4 d...
Source: ChEMBL
Target: Abutilon theophrasti
External Id: CHEMBL1017321
Name: Antimicrobial activity against Aspergillus parasiticus MTCC 2797 assessed as growth i...
Source: ChEMBL
Target: Aspergillus parasiticus
External Id: CHEMBL3074439
Name: Herbicidal activity against velvetleaf assessed as seed germination at 2.5 mM after 4...
Source: ChEMBL
Target: Abutilon theophrasti
External Id: CHEMBL1017320
Name: Antimicrobial activity against Aspergillus sydowii MTCC 4335 assessed as growth inhib...
Source: ChEMBL
Target: Aspergillus sydowii
External Id: CHEMBL3074438
Name: Antimicrobial activity against Pichia kudriavzevii MTCC 231 assessed as growth inhibi...
Source: ChEMBL
Target: Pichia kudriavzevii
External Id: CHEMBL3074441
Name: Antimicrobial activity against Aspergillus niger MTCC 404 assessed as growth inhibiti...
Source: ChEMBL
Target: Aspergillus niger
External Id: CHEMBL3074440
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

3-(4-Methoxyphenyl)-2-propenal
3-p-methoxyphenyl-2-propenal
p-Methoxycinnamaldehyde
4-Methoxycinnamaldehyde
4-Methoxybenzeneacrolein
Einecs 217-807-0
4-Methoxyciamaldehyde
Fema no. 3567
3-(4-Methoxyphenyl)acrylaldehyde
VH1U1R DO1
trans-4-Methoxycinnamaldehyde
para-methoxycinnamaldehyde
Methoxycinnamaldehyde,p
4-Methoxybenzenepropenal

 4-Methoxycinnamaldehyde | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the downstream products of p-Methoxycinnamic aldehyde?
A: Related downstream products(CAS) of p-Methoxycinnamic aldehyde: 4964-76-5;100-09-4;637-69-4;25163-70-6;20401-88-1;830-09-1;832-01-9;5406-18-8;16032-40-9;15542-37-7.
Q: What is the molecular formula of p-Methoxycinnamic aldehyde?
A: Molecular formula of p-Methoxycinnamic aldehyde is C10H10O2.
Q: What is the melting point of p-Methoxycinnamic aldehyde?
A: Melting point of p-Methoxycinnamic aldehyde is 55-60ºC(lit.).
Q: What English synonyms does p-Methoxycinnamic aldehyde have?
A: English synonyms of p-Methoxycinnamic aldehyde: 3-(4-Methoxyphenyl)-2-propenal, 3-p-methoxyphenyl-2-propenal, p-Methoxycinnamaldehyde, 4-Methoxycinnamaldehyde, 4-Methoxybenzeneacrolein, Einecs 217-807-0, 4-Methoxyciamaldehyde, Fema no. 3567, 3-(4-Methoxyphenyl)acrylaldehyde, VH1U1R DO1, trans-4-Methoxycinnamaldehyde, para-methoxycinnamaldehyde, Methoxycinnamaldehyde,p, 4-Methoxybenzenepropenal.
Q: What is the safety information for p-Methoxycinnamic aldehyde?
A: Safety information for p-Methoxycinnamic aldehyde: 26-36.
Q: What is the polar surface area (PSA) of p-Methoxycinnamic aldehyde?
A: Polar surface area (PSA) of p-Methoxycinnamic aldehyde is 26.30000.
Q: What is the English name of p-Methoxycinnamic aldehyde?
A: The English name of p-Methoxycinnamic aldehyde is p-Methoxycinnamic aldehyde.
Q: What is the molecular weight of p-Methoxycinnamic aldehyde?
A: Molecular weight of p-Methoxycinnamic aldehyde is 162.185.
Q: What is the boiling point of p-Methoxycinnamic aldehyde?
A: Boiling point of p-Methoxycinnamic aldehyde is 308.7±17.0 °C at 760 mmHg.
Q: What are the upstream materials of p-Methoxycinnamic aldehyde?
A: Related upstream materials(CAS) of p-Methoxycinnamic aldehyde: 104-45-0;140-67-0;104-46-1;71277-02-6;19115-30-1.

 4-Methoxycinnamaldehydefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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