53-42-9
53-42-9 structure
- Name: Etiocholanolone
- Chemical Name: 3α-hydroxy-5β-androstan-17-one
- CAS Number: 53-42-9
- Molecular Formula: C19H30O2
- Molecular Weight: 290.440
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2018-05-08 08:00:00
- Modify Date: 2026-07-02 06:00:15
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Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form[2].
| Name | 3α-hydroxy-5β-androstan-17-one |
|---|---|
| Synonyms |
ETIOCHOLANOLONE VETRANAL
3α-Hydroxy-5β-androstan-17-one, 5β-Androsterone, Etiocholanone 5β-Androsterone 5-Isoandrosterone 3α-Hydroxy-5β-androstane-17-one Androstan-3α-ol-17-one (Etiocholanolone) (solution) 3α-Etiocholanolone Androstan-17-one, 3-hydroxy-, (3alpha,5beta) 5b-Androsterone 5β-Androstan-3α-ol-17-one-16,16-D2 Gamma-aminobutyric acid Rector,γ-Aminobutyric acid Rector,anticonvulsant,Etiocholanolone,GABA Rector,ilsyantiiltic,5β-Androsterone,inhibit,Inhibitor ETIOCHOLANOLONE(RG) ETIOCHOLAN-3A-OL-17-ONE 5BETA-ANDROSTAN-3ALPHA-OL-17-ON 5β-Androstero Etiocholan-3α-ol-17-one ETICHOLAN-3ALPHA-OL-17-ONE etiocholan-3A-ol-17-one crystalline 3alpha-hydroxy-5beta-androstan-17-one Androstan-17-one, 3-hydroxy-, (3α,5β) (5β)-Androsterone 5BETA-ANDROSTAN-3A-OL-17-ONE (3α,5β)-3-Hydroxyandrostan-17-one Androstan-3α-ol-17-one (Etiocholanolone) in Methanol ETIOCHOLAN-3ALPHA-OL-17-ONE ETIOCHOLANOLON Androstan-3alpha-ol-17-one 19-noretiocholanolone 3a-Etiocholanolone Etiocholan-3α-ol-17-one,3α-Hydroxy-5β-androstan-17-one, 5β-Androsterone, Etiocholanone 3a-hydroxy-5b-androstan-17-one Androsterone, (5beta) androstan-3α-ol-17-one (Etiocholanolone) 5BETA-ANDROSTAN-3ALPHA-OL-17-ONE 3α-Hydroxyetiocholan-17-one Etiocholan-3a-ol-17-one 5β-Androstane-3α-ol-17-one 5β-Androstan-3α-ol-17-one (Etiocholanolone) 3α-hydroxy-5β-androstane-17-one 3ALPHA-ETIOCHOLANOLONE Androstan-17-one,3-hydroxy-, (3a,5b) ETIOCHOLANOLONE EINECS 200-835-2 3a-Hydroxy-5b-androstane-17-one (5b)-Androsterone 5BETA-ANDROSTERONE MFCD00064133 5-β-Androstan-3-α-ol-17-one 5beta-Androstan-17-one, 3alpha-hydroxy etiocholan-3A-ol-l7-one crystalline (3R,5R,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one ETIOCHOLANONE 5-Androstan-3a-ol-17-one-d2 3alpha-Hydroxyetiocholan-17-one etiocholan-3α-ol-17-one Rocuronium bromide Impurity 48 Etiocholanone solution C04373 Etiocholan-3.α.-ol-17-one 3ALPHA-HYDROXY-5BETA-ANDROSTAN-17-ONE ETIOCHOLANOLONE (5B-ANDROSTAN-3A-OL-17-O NE) |
| Description | Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form[2]. |
|---|---|
| Related Catalog | |
| In Vitro | Etiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it is ineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect)[2]. |
| In Vivo | Etiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50 values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 413.1±45.0 °C at 760 mmHg |
| Melting Point | 148～150°C (lit.) |
| Molecular Formula | C19H30O2 |
| Molecular Weight | 290.440 |
| Flash Point | 176.4±21.3 °C |
| Exact Mass | 290.224579 |
| PSA | 37.30000 |
| LogP | 3.75 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.536 |
| Storage condition | 2-8°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | F,Xn |
| Risk Phrases | 11-20/21/22-36 |
| Safety Phrases | 16-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| Precursor 9 | |
|---|---|
| DownStream 1 | |
