128-20-1

128-20-1 structure

Name: Pregnanolone
Chemical Name: 3α-hydroxy-5β-pregnan-20-one
CAS Number: 128-20-1
Molecular Formula: C₂₁H₃₄O₂
Molecular Weight: 318.493
Create Date: 2018-07-24 10:08:56
Modify Date: 2025-08-25 15:34:44
Pregnanolone, also known as 3a5b-Pregnanolone; Kabi-2213, SKF 6455, Eltanolone, is a cell membrane modulator potentially for the treatment of pain. Pregnanolone is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA receptor, as well as a negative allosteric modulator of the glycine receptor, and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects. It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for that reason was never marketed.

Name	3α-hydroxy-5β-pregnan-20-one
Synonyms	MFCD00067137 Pregnanolone II 5-Pregnan-3-ol-20-one pregnanalone Pregnan-20-one, 3-hydroxy-, (3α)- PREGNAN-3A-OL-20-ONE 3alpha-hydroxy-5beta-pregnan-20-one (3α)-3-Hydroxypregnan-20-one Pregnan-20-one,3-hydroxy-, (3a,5b)- Butabindide oxalate

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H351
Precautionary Statements	P281
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn: Harmful;
Risk Phrases	R40
Safety Phrases	22-36
RIDADR	NONH for all modes of transport
RTECS	TU4384000