128-20-1
128-20-1 structure
- Name: Pregnanolone
- Chemical Name: 3α-hydroxy-5β-pregnan-20-one
- CAS Number: 128-20-1
- Molecular Formula: C21H34O2
- Molecular Weight: 318.493
- Create Date: 2018-07-24 10:08:56
- Modify Date: 2026-07-02 17:08:17
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Pregnanolone, also known as 3a5b-Pregnanolone; Kabi-2213, SKF 6455, Eltanolone, is a cell membrane modulator potentially for the treatment of pain. Pregnanolone is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA receptor, as well as a negative allosteric modulator of the glycine receptor, and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects. It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for that reason was never marketed.
| Name | 3α-hydroxy-5β-pregnan-20-one |
|---|---|
| Synonyms |
pregnan-3a-ol-20-one
3α,5β-Pregnanolone MFCD00067137 ELTANOLONE 5A-PREGNAN-3SS-OL-20-ONE Pregnan-20-one, 3-hydroxy-, (3a,5b) 5B-PREGNAN-3A-OL-20-ONE pregnanalone 5BETA-PREGNAN-3ALPHA-OL-20-ONE 3ALPHA-HYDROXY-5BETA-TETRAHYDRO-PROGESTERONE PREGNAN-3A-OL-20-ONE Kabi-2213 (3α)-3-Hydroxypregnan-20-one Butabindide oxalate Kabi2213 IPREGNANOLONE 3-Deoxo-3α-hydroxy-5β-dihydroprogesterone Pregnanolone-[d5] in Methanol 5-Pregnan-3-ol-20-one 1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone Pregnan-20-one, 3-hydroxy-, (3α,5β) 3α-Hydroxy-5β-tetrahydroprogesterone 3a,5b-imeric pregnanolone 3alpha,5beta-Pregnanolone 3α-Hydroxy-5β-pregnan-20-one, 3α-Hydroxy-5β-tetrahydroprogesterone, Pregnanolone Kabi 3α-Hydroxy-20-oxo-5β-pregnane PREGNANOLONE 5beta-Pregnan-3a-ol-20-one Pregnanolone II Pregnan-20-one, 3-hydroxy-, (3alpha,5beta) 3A-HYDROXY-5B-PREGNAN-20-ONE 3a,5b-Tetrahydroprogesterone 3alpha,5beta-imeric pregnanolone 3-alpha-hydroxy-5-beta-pregnan-20-on 3ALPHA-HYDROXY-5BETA-PREGNAN-20-ONE 5-β-Pregnan-3a-ol-20-one 3alpha-hydroxy-5beta-pregnan-20-one 5beta-Pregnan-20-one, 3alpha-hydroxy Pregnanolone (Solution) 5A-PREGNAN-3A-OL-20-ONE 5A-PREGNAN-3B-OL-20-ONE ENTERPRISE STANDD 3a-Hydroxy-5b-tetrahydroprogesterone 5β-Pregnan-3α-ol-20-one 5B-Pregnan-3α-ol-20-one Pregnan-3alpha-ol-20-one Pregnan-3α-ol-20-one (3α,5β)-3-Hydroxy-pregnan-20-one |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 431.2±18.0 °C at 760 mmHg |
| Melting Point | 149ºC |
| Molecular Formula | C21H34O2 |
| Molecular Weight | 318.493 |
| Flash Point | 183.9±13.8 °C |
| Exact Mass | 318.255890 |
| PSA | 37.30000 |
| LogP | 4.89 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.524 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H351 |
| Precautionary Statements | P281 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R40 |
| Safety Phrases | 22-36 |
| RIDADR | NONH for all modes of transport |
| RTECS | TU4384000 |
| Precursor 8 | |
|---|---|
| DownStream 4 | |
