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2545-00-8

2545-00-8 structure
2545-00-8 structure
  • Name: (+)-Afzelechin
  • Chemical Name: afzelechin
  • CAS Number: 2545-00-8
  • Molecular Formula: C15H14O5
  • Molecular Weight: 274.269
  • Catalog: Natural product Flavonoids
  • Create Date: 2017-12-10 07:37:37
  • Modify Date: 2024-01-02 14:41:18
  • (+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an alpha-glucosidase activity inhibitor with an ID50 (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin can delay the absorption of carbohydrates in food to suppress postprandial hyperglycemia and hyperinsulinemia[1].

Name afzelechin
Synonyms (2R,3R)-2-(4-Hydroxyphenyl)-3,5,7-chromanetriol
(-)-epiafzelechin
2H-1-Benzopyran-3,5,7-triol, 3,4-dihydro-2-(4-hydroxyphenyl)-, (2R,3R)-
Afzelechin
2H-1-Benzopyran-3,5,7-triol, 3,4-dihydro-2-(4-hydroxyphenyl)-, (2R,3S)-
(2R,3R)-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
epi-Afzelechin
3,5,7,4'-Tetrahydroxyflavan
(2R,3S)-2-(4-Hydroxyphenyl)-3,5,7-chromanetriol
2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
Description (+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an alpha-glucosidase activity inhibitor with an ID50 (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin can delay the absorption of carbohydrates in food to suppress postprandial hyperglycemia and hyperinsulinemia[1].
Related Catalog
Target

ID50: 0.13 mM (alpha-glucosidase)[1]

References

[1]. Junichi Saijyo, et al. Alpha-glucosidase Inhibitor From Bergenia Ligulata. J Oleo Sci. 2008;57(8):431-5.

Density 1.5±0.1 g/cm3
Boiling Point 583.4±50.0 °C at 760 mmHg
Molecular Formula C15H14O5
Molecular Weight 274.269
Flash Point 306.6±30.1 °C
Exact Mass 274.084137
PSA 90.15000
LogP 1.09
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.709
Hazard Codes Xi