83148-91-8

83148-91-8 structure

Name: sophoridine
Chemical Name: Sophoridine
CAS Number: 83148-91-8
Molecular Formula: C₁₅H₂₄N₂O
Molecular Weight: 248.36
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-03-21 08:00:00
Modify Date: 2024-01-03 14:02:30
d-Sophoridine ((+)-Sophoridine) is the dextro isoform of Sophoridine (HY-N1373), which is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity[1].

Name	Sophoridine
Synonyms	matridin-15-one (2R,3R)-2,3-bis(4-hydroxy-3-methoxybenzyl)-4-butanolide S-GINSENOSIDE RG3 (2R,3R)-2,3-bis(4-hydroxy-3-methoxybenzyl)butyrolactone (3R,4R)-rel-Dihydro-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone (E)-3,4-di[(4-hydroxy-3-methoxyphenyl)methyl]dihydro-2(3H)-furanone SOPHORIDINE (REFERENCE GRADE) MATRIDIN-15-ONE, (6B,7B,11A)- rac Matairesinol (8R,8'R)-(-)-matairesinol Allomatrine trans-Dihydro-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone

Description	d-Sophoridine ((+)-Sophoridine) is the dextro isoform of Sophoridine (HY-N1373), which is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Xu Z, et al. Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells. J Exp Clin Cancer Res. 2017 Sep 11;36(1):124.