Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pravastatin Lactone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

85956-22-5

85956-22-5 structure

Name: Pravastatin Lactone
Chemical Name: [(1S,3S,7S,8S,8aR)-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
CAS Number: 85956-22-5
Molecular Formula: C₂₃H₃₄O₆
Molecular Weight: 406.51
Catalog: Signaling Pathways Metabolic Enzyme/Protease HMG-CoA Reductase (HMGCR)
Create Date: 2018-05-16 08:00:00
Modify Date: 2026-07-01 08:31:43
Pravastatin lactone is a potent HMG-CoA inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis[1].

Name	[(1S,3S,7S,8S,8aR)-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
Synonyms	(1S)-1β-[2-[[(2R,4R)-3,4,5,6-Tetrahydro-4β-hydroxy-6-oxo-2H-pyran]-2-yl]ethyl]-1,2,6,7,8,8aβ-hexahydro-2β-methyl-8α-[[(S)-2-methyl-1-oxobutyl]oxy]naphthalen-6β-ol [14C]-Pravastatin lactone pravastatin Pravastatin Impurity (1S,3S,7S,8S,8-3-Hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-7-methyl-1 Pravastatin Lactone_x000b_ Pravastatin Impurity D (Pravastatin Lactone) Pravastatin Sodium Impurity Ⅲ:Pravastatin Impurity D (Pravastatin Lactone) Pravastatin Impurity10 (1S,3S,7S,8S,8-3-Hydroxy-8-[2-[( Pravastatin IMpurity D (2S)-2-Methyl-Butanoic Acid (1S,3S,7S,8S,8-1,2,3,7,8,8a-hexahydro-3-hydroxy-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester Pravastatin lactone Pravastatin sodium specified impurity D [EP] (1S,3S,7S,8S,8-3-Hydroxy-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate UNII-JBE3Z4192Q PRAVASTATIN SODIUM(RG) Pravastatin class ester Pravastatin Impurity 4（Pravastatin Impurity D） Pravastatin LactoneQ: What is Pravastatin Lactone Q: What is the CAS Number of Pravastatin Lactone Q: What is the storage condition of Pravastatin Lactone Butanoic acid, 2-methyl-, (1S,3S,7S,8S,8-1,2,3,7,8,8a-hexahydro-3-hydroxy-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S) UNII:JBE3Z4192Q (1S,3S,7S,8S,8-3-Hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate Pravastatin Sodium Impurity D [(1S,3S,7S,8S,8-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate (1S,3S,7S,8S,8aR)-3-Hydroxy-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate HMS2090H21

Description	Pravastatin lactone is a potent HMG-CoA inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
References	[1]. Corsini A, et, al. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res. 1995 Jan;31(1):9-27.

Density	1.2±0.1 g/cm3
Boiling Point	590.5±50.0 °C at 760 mmHg
Melting Point	140-143ºC
Molecular Formula	C₂₃H₃₄O₆
Molecular Weight	406.51
Flash Point	199.5±23.6 °C
Exact Mass	406.235535
PSA	93.06000
LogP	1.71
Vapour Pressure	0.0±3.8 mmHg at 25°C
Index of Refraction	1.548

Precursor 4
143842-76-6 143842-75-5 1027991-10-1 143842-79-9
DownStream 0

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