Name | 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one |
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Synonyms |
UNII-51HZG6MP1K
MK-2206 dihydrochloride |
Description | MK-2206 free base is an orally active, highly potent and selective allosteric Akt inhibitor, with IC50s of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. Many breast cancer cell lines, and PIK3CA-mutant and cell lines with PTEN loss are sensitive to MK-2206 free base. MK-2206 free base has anticancer activities[1][2]. |
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Related Catalog | |
Target |
Akt1:8 nM (IC50) Akt2:12 nM (IC50) Akt3:65 nM (IC50) |
References |
[1]. Li Yan, et al. Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor. 2009. |
Molecular Formula | C25H21N5O |
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Molecular Weight | 407.46700 |
Exact Mass | 407.17500 |
PSA | 89.33000 |
LogP | 5.35530 |