MK-2206 free base

Modify Date: 2024-04-05 14:37:41

MK-2206 free base structure	Common Name	MK-2206 free base
	CAS Number	1032349-93-1	Molecular Weight	407.46700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₁N₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MK-2206 free base

MK-2206 free base is an orally active, highly potent and selective allosteric Akt inhibitor, with IC50s of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. Many breast cancer cell lines, and PIK3CA-mutant and cell lines with PTEN loss are sensitive to MK-2206 free base. MK-2206 free base has anticancer activities[1][2].

Name	8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one
Synonym	More Synonyms

Description	MK-2206 free base is an orally active, highly potent and selective allosteric Akt inhibitor, with IC50s of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. Many breast cancer cell lines, and PIK3CA-mutant and cell lines with PTEN loss are sensitive to MK-2206 free base. MK-2206 free base has anticancer activities[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Akt1:8 nM (IC50) Akt2:12 nM (IC50) Akt3:65 nM (IC50)
References	[1]. Li Yan, et al. Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor. 2009. [2]. Zhao YY, et al. Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo. Drug Des Devel Ther. 2014 Oct 10;8:1827-37. [3]. Xing Y, et al. Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation. Breast Cancer Res. 2019 Jul 5;21(1):78. [4]. Agarwal E, et al. Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer. BMC Cancer. 2014 Mar 1;14:145. [5]. Zhao YY, et al. Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo. Drug Des Devel Ther. 2014 Oct 10;8:1827-37.

Molecular Formula	C₂₅H₂₁N₅O
Molecular Weight	407.46700
Exact Mass	407.17500
PSA	89.33000
LogP	5.35530

UNII-51HZG6MP1K

MK-2206 dihydrochloride

MK-2206 free base

Use of MK-2206 free base

Names

MK-2206 free base Biological Activity

Chemical & Physical Properties

Synonyms