64421-28-9

64421-28-9 structure

Name: Shanzhiside methylester
Chemical Name: shanzhiside methyl ester
CAS Number: 64421-28-9
Molecular Formula: C₁₇H₂₆O₁₁
Molecular Weight: 406.382
Catalog: Natural product Iridoid derivative
Create Date: 2018-09-23 09:45:54
Modify Date: 2025-08-23 11:08:25
Shanzhiside methy lester is isolated from L. rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance[1].

Name	shanzhiside methyl ester
Synonyms	Methyl (1S,4aS,5R,7S,7aS)-1-(β-D-glucopyranosyloxy)-5,7-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate shanziside Me-ester shanziside methyl ester shanzhiside methy ester Shanzhiside methylester Shanzhiside methyl ester hanzhiside Methyl ester Shaniside methyl ester shanzhiside Me ester

Description	Shanzhiside methy lester is isolated from L. rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor
Target	IC50: GLP-1 receptor[1]
In Vivo	Shanzhiside methyl ester exerts dose-dependent and long-lasting (>4 h) anti-allodynic effects in spinal nerve injury-induced neuropathic rats, with a maximal inhibition of 49% and a projected ED50 of 40.4 μg[1].
References	[1]. Fan H, et al. Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression.Neuropharmacology. 2016 Feb;101:98-109.

Safety Phrases	22-24/25