64421-28-9

• 常用中文名：山栀苷甲酯
• 常用英文名：Shanzhiside methylester
• CAS号：64421-28-9
• 分子式：C₁₇H₂₆O₁₁
• 分子量：406.382
• 相关类别： 天然产物 环烯醚萜衍生物
• 发布时间：2018-09-23 09:45:54
• 更新时间：2026-07-01 10:51:07
• Shanzhiside methyl ester 是从轮状乳杆菌中分离得到的。Shanzhiside methyl ester 是一种小分子胰高血糖素样肽 1 (GLP-1 receptor) 受体激动剂,具有诱导抗异常性痛觉耐受的能力。

名称

• 中文名: 山栀苷甲酯
• 英文名: shanzhiside methyl ester
• 中文别名: 山栀苷甲酯(山栀甙甲酯; 山栀苷甲酯(山栀子苷甲酯/三栀子甙甲酯/山栀甙甲酯); (1S,4AS,5R,7S,7AS)-5,7-二羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4A,5,6,7,7A-六氢环戊并[C]吡喃-4-甲酸甲酯; 山栀苷甲酯、三栀子甙甲酯; 山栀苷甲酯, 来源于独一味; 山芝皂苷甲酯; 山栀苷甲酯(山栀甙甲酯、三栀子甙甲酯); 山栀苷甲酯(对照品); 三栀子甙甲酯; 山栀甙甲酯; 三栀子甙甲酯|||山芝皂苷甲酯; 山栀苷甲酯(标准品); 独一味黄酮; SHANZHISIDE METHYLESTER 山栀苷甲酯; 山栀苷甲酯Shanzhiside methylester; 山栀甙甲酯、三栀子甙甲酯; 山楂苷甲酯; Shanzhiside methyl ester #天然产物 HY-N0630
• 英文别名: Flavonoids Duyiwei; Cyclopenta[c]pyran-4-cboxylicacid, 1-(b-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-5,7-dihydroxy-7-methyl-,methyl ester, (1S,4aS,5R,7S,7aS); Shanzhisize methyl ester; Cyclopenta[c]pyran-4-cboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-5,7-dihydroxy-7-methyl-, methyl ester, (1S,4aS,5R,7S,7aS); (1S)-1α-(β-D-Glucopyranosyloxy)-5α,7α-dihydroxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-cboxylic acid methyl ester; Shaniside methyl ester; shanzhiside Me ester; Shanzhiside Methylester(P); 1α-(β-D-Glucopyranosyloxy)-5α,7α-dihydroxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-cboxylic acid methyl ester; Shanzhiside methyl ester from Lamiophlomis rotata (Benth. ex Hook.f.) Kud; Methyl (1S,4aS,5R,7S,7aS)-5,7-dihydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-cboxylate; methyl (1S,4aS,5R,7S,7aS)-1-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-cboxylate; Methyl (1S,4aS,5R,7S,7aS)-1-(β-D-glucopyranosyloxy)-5,7-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate; 1α-(β-D-Glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-5α,7α-dihydroxy-7-methylcyclopenta[c]pyran-4-cboxylic acid methyl ester; shanziside Me-ester; Shanzhiside methyl ester-RM; shanzhiside methy ester; Geniposide methyl ester; SHANZHISIDE METHYL ESTER; SHANZHISIDE METHYLESTER; hanzhiside Methyl ester; Bone rair material with rhBMP-2 - Bone rair; (1S)-1α-(β-D-Glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-5α,7α-dihydroxy-7β-methylcyclopenta[c]pyran-4-cboxylic acid methyl ester; methyl (1S,4aS,5R,7S,7aS)-5,7-dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4a,5,6,7a-tetrahydro-1H-cyclopenta[c]pyran-4-cboxylate; Cyclopenta(C)pyran-4-cboxylicacid,1-(beta-D-glucopyranosyloxy)-1,4A,5,6,7,7A-hexahydro-5,7-dihydroxy-7-Methyl-,Methylester,(1S-(1alpha,4aalpha,5alpha,7alpha,7aalpha)); (1S-(1alpha,4aalpha,5alpha,7alpha,7aalpha))-1-(beta-D-Glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-5,7-dihydroxy-7-methylcyclopenta[c]pyran-4-cboxylic acid methyl ester; shanziside methyl ester; Shanzhiside methyl ester; methyl (1S,4aS,5R,7S,7aS)-1-(beta-D-glucopyranosyloxy)-5,7-d; 1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-5,7-dihydroxy-7-methyl-, methyl ester, (1S-(1alpha,4aalpha,5alpha,7alpha,7aalpha))

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 651.4±55.0 °C at 760 mmHg
• 熔点: 90ºC (dec.)
• 分子式: C₁₇H₂₆O₁₁
• 分子量: 406.382
• 闪点: 233.0±25.0 °C
• 精确质量: 406.147522
• PSA: 175.37000
• LogP: -3.25
• 蒸汽压: 0.0±4.4 mmHg at 25°C
• 折射率: 1.621

生物活性

• 描述: Shanzhiside methyl ester 是从轮状乳杆菌中分离得到的。Shanzhiside methyl ester 是一种小分子胰高血糖素样肽 1 (GLP-1 receptor) 受体激动剂,具有诱导抗异常性痛觉耐受的能力。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胰高血糖素受体
• 靶点:

  IC50: GLP-1 receptor[1]

• 体内研究: 山楂苷甲酯对脊髓神经损伤所致神经病变大鼠具有剂量依赖性和持久(>4h)的抗超敏作用,最大抑制率为49%,预计ED50为40.4μg[1]。
• 参考文献:

  [1]. Fan H, et al. Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression.Neuropharmacology. 2016 Feb;101:98-109.

安全

• 安全声明 (欧洲): 22-24/25