89520-11-6

89520-11-6 structure

Name: N-Bromoacetyl-β-alanine
Chemical Name: 3-[(2-bromoacetyl)amino]propanoic acid
CAS Number: 89520-11-6
Molecular Formula: C₅H₈BrNO₃
Molecular Weight: 210.02600
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2016-08-18 07:36:34
Modify Date: 2024-01-20 23:21:53
N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	3-[(2-bromoacetyl)amino]propanoic acid
Synonyms	N-Bromoacetyl-\|A-alanine

Description	N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain Cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Density	1.682g/cm3
Boiling Point	433.4ºC at 760 mmHg
Molecular Formula	C₅H₈BrNO₃
Molecular Weight	210.02600
Flash Point	215.9ºC
Exact Mass	208.96900
PSA	69.89000
LogP	0.81250
Index of Refraction	1.523

Hazard Codes	Xi

614760-41-7

89520-11-6

Literature: Erlanson, Daniel A.; McDowell, Robert S.; He, Molly M.; Randal, Mike; Simmons, Robert L.; Kung, Jenny; Waight, Andrew; Hansen, Stig K. Journal of the American Chemical Society, 2003 , vol. 125, # 19 p. 5602 - 5603

598-21-0

107-95-9

89520-11-6

Literature: Baker,B.R.; Santi,D.V. Journal of Pharmaceutical Sciences, 1967 , vol. 56, p. 380 - 384

Precursor 3
614760-41-7 598-21-0 107-95-9
DownStream 1
57159-62-3

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