DC Chemicals Limited
China
Product Name: KW-8232
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

217813-15-5

217813-15-5 structure

Name: KW-8232
Chemical Name: [4-[[2-[4-(2-chlorophenyl)piperazine-1-carbonyl]-1-[2-(dimethylamino)ethyl]indol-3-yl]-(4-hydroxyphenyl)methyl]phenyl] methanesulfonate
CAS Number: 217813-15-5
Molecular Formula: C₃₇H₃₉ClN₄O₅S
Molecular Weight: 687.24700
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2016-04-29 10:30:47
Modify Date: 2024-01-16 21:57:35
KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2[1].

Name	[4-[[2-[4-(2-chlorophenyl)piperazine-1-carbonyl]-1-[2-(dimethylamino)ethyl]indol-3-yl]-(4-hydroxyphenyl)methyl]phenyl] methanesulfonate
Synonyms	kw8232

Description	KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Metabolic Disease
Target	Prostaglandin Receptor[1]
In Vitro	KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells[1]. KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM )[2].
In Vivo	KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production[1]. Animal Model: male Sprague-Dawley rats (5-week-old)[1]. Dosage: 1, 3, 10, and 30 mg/kg. Administration: Orally once daily beginning 1 day prior to neurectomy for 28 days. Result: Decreased urinary calcium excreation in the neurectomized rats only at 30 mg/kg.
References	[1]. Uchii M, et al. Effect of KW-8232, a novel anti-osteoporotic agent, on bone loss in sciatic neurectomized rats. Jpn J Pharmacol. 1998 Oct;78(2):241-3. [2]. Shiwei Wang, et al. A Transferable Deep Learning Approach to Fast Screen Potent Antiviral Drugs against SARS-CoV-2. bioRxiv. 2020.

Boiling Point	805.5ºC at 760 mmHg
Molecular Formula	C₃₇H₃₉ClN₄O₅S
Molecular Weight	687.24700
Flash Point	440.9ºC
Exact Mass	686.23300
PSA	103.70000
LogP	7.12660
Vapour Pressure	5.44E-27mmHg at 25°C

217813-15-5	170365-25-0
136199-02-5	1000669-72-6
292819-64-8	63233-46-5
127166-41-0	819812-04-9
841259-17-4	214764-26-8