Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Danshensu
Price: ￥498.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Danshensu
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

76822-21-4

76822-21-4 structure

76822-21-4 structure

Name: Danshensu
Chemical Name: (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid
CAS Number: 76822-21-4
Molecular Formula: C₉H₁₀O₅
Molecular Weight: 198.17
Catalog: Biochemical Plant extracts
Create Date: 2018-04-17 08:00:00
Modify Date: 2024-01-02 07:32:34
Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.

Name	(2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid
Synonyms	Danshensu Sodium (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate (2R)-3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoic acid Benzenepropanoic acid, α,3,4-trihydroxy-, (αR)- Benzenepropanoic acid, α,3,4-trihydroxy-, sodium salt, (αR)- (1:1) Salvianic

Description	Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Cardiovascular Disease Natural Products >> Phenylpropanoids
In Vitro	Danshensu (DSS) significantly decreases the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size. This could markedly contribute to the recovery of cardiac function after I/R injury. DSS also has ROS scavenging activity and boosts endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which is mediated by Akt and ERK1/2 in western blot analysis[2].
In Vivo	Acute treatment with a single dose of danshensu in rats with normal tHcy does not change plasma tHcy. In contrast, danshensu significantly lowers tHcy in rats with elevated tHcy. The relatively higher cysteine and glutathione levels after treatment with danshensu indicates that its tHcy-lowering effect is via increased activity of the trans-sulphuration pathway[1].
Animal Admin	All chemicals are dissolved in saline, except for tolcapone which is dissolved in saline containing 20% (v/v) PEG 200. During experiments, rats are fasted overnight and randomLy assigned into different groups. About 200 µL blood is taken from orbital sinus alternatively after ethyl ether anaesthesia, and then the eye is quickly sterilized with alcohol and pressed with cotton. Blood samples are immediately collected into a polypropylene tube containing heparin-Na and centrifuged at 5000 g at 5°C for 3 min. Prepared plasma samples are kept at −20°C and analysed within 48 h.
References	[1]. YG Cao, et al. Beneficial effects of danshensu, an active component of Salvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rats. Br J Pharmacol. 2009 Jun; 157(3): 482–490. [2]. Yu J, et al. Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling. Int J Clin Exp Med. 2015 Sep 15;8(9):14793-804.

Density	1.5±0.1 g/cm3
Boiling Point	481.5±40.0 °C at 760 mmHg
Molecular Formula	C₉H₁₀O₅
Molecular Weight	198.17
Flash Point	259.1±23.8 °C
PSA	97.99000
LogP	-0.29
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.659

Hazard Codes	Xi
HS Code	2942000000

HS Code	2942000000