Shanghai Nianxing Industrial Co., Ltd
China
Product Name: phorbol
Price: Check
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: phorbol
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: phorbol
Price: ￥2748.0/10mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Phorbol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

17673-25-5

17673-25-5 structure

17673-25-5 structure

Name: phorbol
Chemical Name: phorbol
CAS Number: 17673-25-5
Molecular Formula: C₂₀H₂₈O₆
Molecular Weight: 364.43300
Catalog: Research Areas Cancer
Create Date: 2018-10-17 12:46:58
Modify Date: 2025-08-21 10:57:32
Phorbol is a highly toxic diterpene, whose esters have important biological properties.

Name	phorbol
Synonyms	Phorbol,Pentahydroxy-tigliadienon MFCD00065450 4b,9a,12b,13a,20-pentahydroxytiglia-1,6-dien-3-one Phorbol-(3) 4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-et PHORBOL 4BETA,9ALPHA,12BETA,13ALPHA,20-PENTAHYDROXYTIGLIA-1,6-DIEN-3-ONE

Description	Phorbol is a highly toxic diterpene, whose esters have important biological properties.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer
References	[1]. Matsuzawa Y, et al. Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf. J Pharmacol Sci. 2009 Oct;111(2):182-92

Density	1.415 g/cm3
Boiling Point	572ºC at 760 mmHg
Melting Point	250-251ºC DECOMP
Molecular Formula	C₂₀H₂₈O₆
Molecular Weight	364.43300
Flash Point	313.8ºC
Exact Mass	364.18900
PSA	118.22000
Vapour Pressure	1.83E-15mmHg at 25°C
Index of Refraction	1.648
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ0600000

CHEMICAL NAME :: 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one, 1,1a-beta,1b-alpha,4,4a,7a-beta,7b,8,9,9a- decahydro-4a-alpha,7b-alpha,9-beta,9a-alpha-tetrahydr oxy-3-(hydroxymethyl) -1,1,6,8-alpha- tetramethyl-

CAS REGISTRY NUMBER :: 17673-25-5

LAST UPDATED :: 199304

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C20-H28-O6

MOLECULAR WEIGHT :: 364.48

WISWESSER LINE NOTATION :: L E3 B675 MV IU NUTJ BQ C1 DQ EQ F1 F1 JO1 LQ N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

REFERENCE :: PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 22,241,1972 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg/25W

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 30,2744,1970

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 284 mg/kg/39W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

REFERENCE :: JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979- Volume(issue)/page/year: 95,19,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 64 mg/kg

SEX/DURATION :: lactating female 2 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 165,394,1980 *** REVIEWS *** TOXICOLOGY REVIEW CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,1171,1976

Hazard Codes	T+: Very toxic;
Risk Phrases	R26/27/28
Safety Phrases	26-27-36/37/39-45-28
RIDADR	UN 2811 6
WGK Germany	3
RTECS	GZ0600000
Packaging Group	III
Hazard Class	6.1(b)

Precursor 0
DownStream 7
20839-06-9 20839-16-1 19891-06-6 24928-15-2
16561-29-8 83920-66-5 41621-85-6

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