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83919-23-7

83919-23-7 structure
83919-23-7 structure
  • Name: Mometasone furoate
  • Chemical Name: mometasone furoate
  • CAS Number: 83919-23-7
  • Molecular Formula: C27H30Cl2O6
  • Molecular Weight: 521.43
  • Catalog: API Hormone and endocrine-regulating drugs Adrenal corticosteroids
  • Create Date: 2018-09-13 20:10:27
  • Modify Date: 2026-06-30 00:20:28
  • Mometasone furoate, prodrug of the free form mometasone, is a agent with high affinity for the glucocorticoid receptor.IC50 value: Target: glucocorticosteroid receptorMometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma [1]. MF is approved for once or bid maintenance treatment of asthma (in patients previously receiving ICS or bronchodilators). Low systemic bioavailability and high relative binding affinity for the glucocorticoid receptor are properties of MF that allow for a favourable efficacy and tolerability profile. Inhaled MF has been shown to be an effective and well-tolerated controller medication for those patients with mild, moderate or severe persistent asthma [2].
Name mometasone furoate
Synonyms 9,21-Dichloro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-(2-furoate)
Mometasone Furoate Anhydrous
9，21-Dichloro-11β，17-hydrox-16α-methylpregm-1，4-diene-3，20-dione 17-(2-furoate)
(8S,9R,10S,11S,13S,14S,16R,17R)-9-Chloro-17-(chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl 2-furoate
(11-beta,16-alpha)-xy-16-methyl
Pregna-1,4-Diene-3,20-Dione,9,21-Dichloro-17-[(2-Furanylcbonyl)Oxy]-11-Hydroxy-16-Methyl-,(11Beta,16Alpha)
Nosorex
(11β,16α)-9,21-Dichlor-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-ylfuran-2-carboxylat
MometasoneFuorateBp
NASONEX
D3-Mometasone Furoate
Mometasone furoate/Mometasone furoate
(8S,9R,10S,11S,13S,14S,16R,17R)-9-Chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-cboxylate
MFCD00866003
Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-[(2-furanylcbonyl)oxy]-11-hydroxy-16-methyl-, (11β,16α)
(11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl furan-2-carboxylate
2-Furancarboxylic acid, (11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl ester
Mometasone Furoate H0E0090.998mg/mg(dr)
(11β,16α)-9,21-Dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate
Rimelon
Mometasone furoate Solution, 100ppm
(8s,9r,10s,11s,13s,14s,16r,17r)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] Furan-2-cboxylate
Ecural
(8S,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-11,17-diyl bis(furan-2-cboxylate)
srh-32088
9,21-Dichloro-17-[(2-furanylcbonyl)oxy]-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione
Flumeta
pregna-1,4-diene-3,20-dione,9,21-dichloro-17-((2-furanylcbonyl)oxy)-11-hydro
ElocoM
Mometasone furoate CRS
(11BETA,16ALPHA)-9,21-DICHLORO-17-[(2-FURANYLCBONYL)OXY]-11-HYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
Mometasone furoate, 10 mM in DMSO
AsManex
Mometaso Furoate
(11β,16α)-9,21-Dichloro-17-[(2-furanylcbonyl)oxy]-11-hydroxy-16-Methyl-pregna-1,4-diene-3,20-dione
Monovo
Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-[(2-furanylcbonyl)oxy]-11-hydroxy-16-methyl-, (11b,16a)- (9CI)
Mometasone furoate (JAN/USP)
Mometasone furoateQ: What is Mometasone furoate Q: What is the CAS Number of Mometasone furoate Q: What e the applications of Mometasone furoate
Mometasone 17-(2-furoate)
MometasoneFuroate>
MOMETOSONE FUROATE MONOHYDRATE
Mometasone Furoate
SCH-32088
Twisthaler
(8S,9R,10S,11S,13S,14S,16R,17R)-9-Chlor-17-(chloracetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-ylfuran-2-carboxylat
9,21-Dichloro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione17-(2-Furoate)
furane-2-carboxylate de (8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(chloroacétyl)-11-hydroxy-10,13,16-triméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yle
Mometasone furoate //BP
Sch-32088, Elocon, Nasonex
EloMet
[(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
Mometason Furoate
MOMETASONE FUOATE
2-furancboxylic acid [(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloro-1-oxoethyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
(11b,16a)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl furan-2-carboxylate
9,21-Dichloro-17-[[(furan-2-yl)carbonyl]oxy]-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione
9-chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one furoate
MOMETASONE 17-FUROATE
MOMETASONE FUROATE
metasone furoate
Mometasone furoate D3Q: What is Mometasone furoate D3 Q: What is the CAS Number of Mometasone furoate D3 Q: What is the storage condition of Mometasone furoate D3 Q: What e the applications of Mometasone furoate D3
2-furancarboxylic acid, (11b,16a)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl ester
Danitin
9α,21-Dichloro-17α-[[(furan-2-yl)carbonyl]oxy]-11β-hydroxy-16α-methylpregna-1,4-diene-3,20-dione
Mometasone Furoate （DMF）
Flecainida
(11b,16a)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
Flecainidum
(+)-9,21-Dichloro-11',17'-dihydroxy-16-alpha-methyl-1,4-pregnadiene-3,20-dione-17-(2-furoate)
11β,16α)-9,21-Dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl2-furoate
9α,21-Dichloro-11β-hydroxy-16α-methyl-17α-[(2-furanyl)cbonyloxy]pregna-1,4-diene-3,20-dione
AsManex Twisthaler
Mometasone Furoate-13C,d6
Description Mometasone furoate, prodrug of the free form mometasone, is a agent with high affinity for the glucocorticoid receptor.IC50 value: Target: glucocorticosteroid receptorMometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma [1]. MF is approved for once or bid maintenance treatment of asthma (in patients previously receiving ICS or bronchodilators). Low systemic bioavailability and high relative binding affinity for the glucocorticoid receptor are properties of MF that allow for a favourable efficacy and tolerability profile. Inhaled MF has been shown to be an effective and well-tolerated controller medication for those patients with mild, moderate or severe persistent asthma [2].
Related Catalog
References

[1]. Tan RA, et al. Mometasone furoate in the management of asthma: a review. Ther Clin Risk Manag. 2008 Dec;4(6):1201-8.

[2]. Bousquet J. Mometasone furoate: an effective anti-inflammatory with a well-defined safety and tolerability profile in the treatment of asthma. Int J Clin Pract. 2009 May;63(5):806-19.
Density 1.4±0.1 g/cm3
Boiling Point 655.5±55.0 °C at 760 mmHg
Melting Point 218-220°C
Molecular Formula C27H30Cl2O6
Molecular Weight 521.43
Flash Point 350.2±31.5 °C
PSA 113.02000
LogP 4.27
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.604
Storage condition Store at -20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3822000
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydroxy- 16-methyl-, (11-beta,16-alpha)-
CAS REGISTRY NUMBER :
83919-23-7
LAST UPDATED :
199612
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C27-H30-Cl2-O6
MOLECULAR WEIGHT :
521.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,4203,1990
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,4203,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10920 ug/kg/52W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Endocrine - adrenal cortex hypoplasia Blood - changes in spleen
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,4221,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
36400 ug/kg/52W-C
TOXIC EFFECTS :
Liver - other changes Endocrine - adrenal cortex hypoplasia Blood - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,4252,1990 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
210 ug/kg
SEX/DURATION :
female 14 day(s) pre-mating - 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,2505,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
66 ug/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,2517,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
330 ug/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,2517,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
13 ug/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,2517,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
13 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,2545,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
2600 ug/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,2545,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
13 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,2545,1990
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS WW8223000
HS Code 2937229000
HS Code 2937229000
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