Name | Aloe emodin |
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Synonyms |
EINECS 207-571-7
Aloe emodin MFCD00017373 1,8-Dihydroxy-3-(hydroxymethyl)anthracen-9,10-dion 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone ALOE-EMODIN Aloeemodin:9,10-Anthracenedione,1,8-dihydroxy-3-(hydroxymethyl)-, Aloeemodin 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone,3-Hydroxymethylchrysazine,Aloe-emodin 3-Hydroxymethylchrysazine EMODINE 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione Rhabarberone 1,8-Dihydroxy-3-(hydroxymethyl)anthra-9,10-quinone 3-Hydroxymethylchrysazin 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone,3-Hydroxymethylchrysazine 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthraquinone Diacerein impurity B 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)- |
Description | Aloe emodin is a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antitumor activity.IC50 value:Target:in vitro: aloe-emodin treatment led to the dissociation of heat shock protein 90 (HSP90) and ER α and increased ER α ubiquitination. Protein fractionation results suggest that aloe-emodin tended to induce cytosolic ER α degradation [1]. Aloe-emodin, a natural compound found in aloe, inhibited both proliferation and anchorage-independent growth of PC3 cells. Protein content analysis suggested that activation of the downstream substrates of mTORC2, Akt and PKCα, was inhibited by aloe-emodin treatment. Pull-down assay and in vitro kinase assay results indicated that aloe-emodin could bind with mTORC2 in cells and inhibit its kinase activity [2]. Of three anthraquinone derivatives, aloe-emodin, with a lower cytotoxicity showed concentration-dependently reducing virus-induced cytopathic effect and inhibiting replication of influenza A in MDCK cells. Galectin-3 also inhibited influenza A virus replication. Proteomic analysis of treated cells indicated galectin-3 up-regulation as one anti-influenza A virus action by aloe-emodin. Since galectin-3 exhibited cytokine-like regulatory actions via JAK/STAT pathways, aloe-emodin also restored NS1-inhibited STAT1-mediated antiviral responses in transfected cells: e.g., STAT1 phosphorylation of interferon (IFN) stimulation response element (ISRE)-driven promoter, RNA-dependent protein kinase (PKR) and 2'5',-oligoadenylate synthetase (2'5',-OAS) expression [3]. AE downregulated mRNA expression and promoter/gelatinolytic activity of Matrix Metalloproteinase (MMP)-2/9, as well as the RhoB expression at gene and protein level. AE suppressed the nuclear translocation and DNA binding of NF-κB [4].in vivo: Aloe-emodin also exhibited tumor suppression effects in vivo in an athymic nude mouse model [2]. |
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Related Catalog | |
References |
Density | 1.6±0.1 g/cm3 |
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Boiling Point | 568.8±50.0 °C at 760 mmHg |
Melting Point | 223-224°C |
Molecular Formula | C15H10O5 |
Molecular Weight | 270.237 |
Flash Point | 311.9±26.6 °C |
Exact Mass | 270.052826 |
PSA | 94.83000 |
LogP | 3.38 |
Vapour Pressure | 0.0±1.6 mmHg at 25°C |
Index of Refraction | 1.746 |
Storage condition | 2-8°C |
Stability | Hygroscopic |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi |
Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
Safety Phrases | S26-S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | CB6712200 |
Precursor 7 | |
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DownStream 10 | |