Name | Rhein |
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Synonyms |
Rhein
1,8-dihydroxy-3-carboxy-9,10-anthraquinone EINECS 207-521-4 Cassic acid 2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- Rheic acid Rhubarb Yellow 1,8-dihydroxyanthraquinone-3-carboxylic acid 1,8-dihydroxy-3-carboxyanthraquinone 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid MFCD00009618 Monorhein 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid 4,5-Dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid 4,5-Dihydroxyanthraquinone-2-carboxylic acid 9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid Chrysazin-3-carboxylic acid |
Description | Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. IC50 value:Target:In vitro: Rhein (0.1 and 1 mg/mL) evidently suppressed cell proliferation and mitogen-activated protein (MAP) kinase activation in human colon adenocarcinoma cells (Caco-2) but significantly lessened H2O2-induced DNA damage and the elevated MDA and ROS levels induced by H2O2/Fe2+ at the concentrations of 0.1–10 mg/mL [1].In vivo: Oral administration of rhein (150 mg/kg/d) evidently ameliorated renal interstitial fibrotic lesions and attenuated the expression of α-SMA and deposition of fibronectin (FN) in mice with renal interstitial fibrosis induced by unilateral ureteral obstruction. Rhein also suppressed TGF-β1 and its type I receptor expression in obstructed kidneys [1]. The biochemical parameters results of IgAN model rats showed that rhein-prevented and rhein-treated both improved the biochemical parameters and relieved renal pathological injury. The expressions of renal tissue TLR4, TGF-β1, but not TLR9 were significantly elevated in IgAN model rats (P < 0.05). Rhein-prevented and rhein-treated both inhibited TLR4 and TGF-β1 expressions [2]. |
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Related Catalog | |
References |
Density | 1.7±0.1 g/cm3 |
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Boiling Point | 597.8±50.0 °C at 760 mmHg |
Melting Point | ≥300 °C(lit.) |
Molecular Formula | C15H8O6 |
Molecular Weight | 284.220 |
Flash Point | 329.4±26.6 °C |
Exact Mass | 284.032074 |
PSA | 111.90000 |
LogP | 4.58 |
Vapour Pressure | 0.0±1.8 mmHg at 25°C |
Index of Refraction | 1.761 |
Storage condition | 2-8°C |
Water Solubility | <0.1 g/100 mL at 17 ºC |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi |
Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
Safety Phrases | S26-S37/39 |
RIDADR | NONH for all modes of transport |
WGK Germany | 2 |
RTECS | CA9516000 |
HS Code | 2918990090 |
Precursor 9 | |
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DownStream 3 | |
HS Code | 2918990090 |
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Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |