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370-81-0

370-81-0 structure

370-81-0 structure

Name: oxalic bis(cyclohexylidenehydrazide)
Chemical Name: Bis(cyclohexanone)oxaldihydrazone
CAS Number: 370-81-0
Molecular Formula: C₁₄H₂₂N₄O₂
Molecular Weight: 278.350
Catalog: Chemical reagent Organic reagent 肼
Create Date: 2018-05-14 08:00:00
Modify Date: 2026-06-29 17:31:08
Cuprizone is a chelator used as a reagent for copper analysis. Cuprizone is frequently used for studying factors that affect oligodendrocytes death and myelin loss[1][2].

Name	Bis(cyclohexanone)oxaldihydrazone
Synonyms	Bis-Cyclohexanone Oxalyl Dihydrazide Chromium(III) Ionophore III Dicyclohexanoneoxaly dihydrazone BISCYCLOHEXANONE OXALYLDIHYDRAZONE BIS-CYCLOHEXANONE OXALDIHYDRAZONECRYSTAL LINE DICYCLOHEXANONE OXALYLDIHYDRAZONE Oxalybis(cyclohexylidene hydrazone) Dicyclohexanone oxadiazole Bis(cyclohexanone)oxaldihydrazone, for spectrophotoMetric det. of Cu BIS CYCLOHEXANONE OXALYL DIHYDRAZIDE Oxalic acid bis(cyclohexylidenehydrazide) biscyclohexanone CUPFERAZONE CUPRIZONE I Oxalic acid bis (cyclohexylidene hydrazide) for analysis ( for copper) Bicyclic cyclohexanone oxalyl dihydrazone N',N'-Dicyclohexylideneethanedihydrazide Bis(cyclohexanone)oxaldihydrazone for spectrophotometric det. of Cu Oxalic Acid Bis-(Cyclohexylidenehydrazide) Cuprizonl BIS(CYCLOHEXYLIDENE)OXALODIHYDRAZIDE EINECS 206-729-2 ethanedioicacid,bis(cyclohexylidenehydrazide) MFCD00001659 biscyclohexanoneoxadihydrazone dicyclohexanoneoxalyldihydrozone Oxalyl bis(cyclohexylidene hydrazone) OXALIC ACID BIS(CYCLOHEXYLIDENEHYDRAZIDE) TIMTEC-BB SBB008866 Bis(cyclohexanone)oxalyldihydrazone CUPRIZONE Bis(cyclohexanone)ox Bis(cyclohexanone) oxaldihydrazone oxaldihydrazone Oxalic acid bis[N'-(cyclohexylidene) hydrazide] N,N-oxalylbis(cyclohexanone hydrazone) Ethanedioic acid,1,2-bis(2-cyclohexylidenehydrazide) Cupferazone Cuprizone N,N'-bis(cyclohexylideneamino)oxamide CUPRIZON Dicyclohexanoneoxalydihydrazone N'1,N'2-dicyclohexylideneoxalohydrazide Cuprizon,Cuprizone,Oxalic acid bis(cyclohexylidenehydrazide) 6-CHLORO-BENZOXAZOL-2(3H)-ONE, PESTANAL CUPRIZON I Cuprizon, Cuprizone, Oxalic acid bis(cyclohexylidenehydrazide) BIS-CYCLOHEXANONE OXALDIHYDRAZONE, BIS-CYCLOHEXANONE OXALDIHYDRAZONE, BIS-CYCLOHEXANONE OXALDIHYDRAZONE BisCyclohexanoneOxalylDihydrazide Oxalic acid bis Cuprizane Dicyclohexanoneoxalyldihydrazo Bis(cyclohexanone) Oxalyldihydrazone Oxalybis(cyclohexylidene hydrazone) biscyclohexanone CUPRIZON 1 OXALIC ACID BIS (CYCLOHEXYLIDENE HYDRAZI Bis(cyclohexanone)oxaldihydrazone=CuprizonI N,N'-Bis(cyclohexylideneamino)oxamide Ethanedioic acid, bis(2-cyclohexylidenehydrazide) N'1, N'2-Oxalazide (cyclohexylhydrazine) Cupferazone Oxalic acid di(N'-cyclohexylidene hydrazide) 1,2-bis(2-cyclohexylidenehydrazide) Ethanedioic acid

Description	Cuprizone is a chelator used as a reagent for copper analysis. Cuprizone is frequently used for studying factors that affect oligodendrocytes death and myelin loss[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Cuprizone (0.5 mg/100 mg of diet and water given ad lib; p.o.) produces severe status spongious in the CNS, most prominently in the brain stem and cerebellar white matter of mice[1].
References	[1]. Suzuki K, et al. Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone). Am J Pathol. 1969 Feb;54(2):307-25. [2]. Sanadgol N, et al. Alpha-lipoic acid mitigates toxic-induced demyelination in the corpus callosum by lessening of oxidative stress and stimulation of polydendrocytes proliferation. Metab Brain Dis. 2018 Feb;33(1):27-37.

Density	1.3±0.1 g/cm3
Melting Point	210-214 °C(lit.)
Molecular Formula	C₁₄H₂₂N₄O₂
Molecular Weight	278.350
Exact Mass	278.174286
PSA	82.92000
LogP	0.85
Index of Refraction	1.626
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RO2520000

CHEMICAL NAME :: Oxalic acid, bis(cyclohexylidenehydrazide)

CAS REGISTRY NUMBER :: 370-81-0

BEILSTEIN REFERENCE NO. :: 2388004

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H22-N4-O2

MOLECULAR WEIGHT :: 278.40

WISWESSER LINE NOTATION :: L6YTJ AUNMVVMNU- AL6YTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 29400 mg/kg/7W-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20160 mg/kg/8W-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 24 gm/kg

SEX/DURATION :: female 3-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 gm/kg

SEX/DURATION :: female 3-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/14D (Continuous)

REFERENCE :: EJBCAI European Journal of Biochemistry. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967- Volume(issue)/page/year: 47,313,1974

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R21/22
Safety Phrases	S24/25-S2
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RO2520000
Packaging Group	I; II; III
Hazard Class	6.1
HS Code	29280090

996-98-5 structure

996-98-5

108-94-1 structure

108-94-1

~%

370-81-0 structure

370-81-0

Literature: Peterson; Bollier Analytical Chemistry, 1955 , vol. 27, p. 1195 Full Text View citing articles Show Details Vanghelovici et al. Acad. Timisoara Stud. Cerc. med., 1962 , vol. 9, p. 143,147

Precursor 2
996-98-5 108-94-1
DownStream 0

HS Code	2928000090
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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