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2318-18-5

2318-18-5 structure
2318-18-5 structure
  • Name: Senkirkine
  • Chemical Name: senkirkin
  • CAS Number: 2318-18-5
  • Molecular Formula: C19H27NO6
  • Molecular Weight: 365.42100
  • Catalog: analytical chemistry Standard Food and cosmetics standards
  • Create Date: 2018-10-03 00:01:35
  • Modify Date: 2025-08-20 09:28:14
  • Senkirkin, a pyrrolizidine alkaloid, occured in the aerial parts of the medicinal plant Tussilago farfara, could induce chromosome damage in human lymphocytes[1].
Name senkirkin
Synonyms renardin
12-Hydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione,Renardine
RENARIDINE
Kushenin
Senkarkane
12-hydroxy-4-methyl-4,8-seco-senecionane-8,11,16-trione
SENKIKIN
Description Senkirkin, a pyrrolizidine alkaloid, occured in the aerial parts of the medicinal plant Tussilago farfara, could induce chromosome damage in human lymphocytes[1].
Related Catalog
References

[1]. C Kraus, G Abel, et al. [Pyrrolizidine Alkaloids With Chromosome-Damaging Effects on Human Lymphocytes in Vitro]. Planta Med. 1985 Apr;(2):89-91.
Density 1.22g/cm3
Boiling Point 604.9ºC at 760 mmHg
Melting Point 198ºC
Molecular Formula C19H27NO6
Molecular Weight 365.42100
Flash Point 319.6ºC
Exact Mass 365.18400
PSA 93.14000
LogP 0.94740
Vapour Pressure 3.72E-17mmHg at 25°C
Index of Refraction 1.546
Storage condition ?20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VT5960000
CHEMICAL NAME :
Senecionanium, 8,12-dihydroxy-4-methyl-11,16-dioxo-
CAS REGISTRY NUMBER :
2318-18-5
LAST UPDATED :
199510
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C19-H27-N-O6
MOLECULAR WEIGHT :
365.47
WISWESSER LINE NOTATION :
T55-12- 1A Q EK IOVY OVO BUTJ DQ E1 KU2 M1 NQ N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Liver - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1320 mg/kg/56W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
600 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 142,209,1985 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,231,1983 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,327,1976 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW PPTCBY Proceedings of the International Symposium of the Princess Takamatsu Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku, Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 9,79,1979
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Hazard Codes Xn
Risk Phrases 22
RIDADR UN 1544
Packaging Group III
Hazard Class 6.1(b)
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