4085-31-8

• 常用中文名：磷酸哌喹
• 常用英文名：piperaquine phosphate
• CAS号：4085-31-8
• 分子式：C₂₉H₃₂Cl₂N₆
• 分子量：535.511
• 相关类别： 原料药 抗寄生虫病药 抗疟药
• 发布时间：2018-04-22 08:00:00
• 更新时间：2026-06-30 16:42:19
• 哌喹是一种双喹啉抗疟剂。哌喹可与青蒿素联合用于抗疟研究[1][2]。

名称

• 中文名: 磷酸哌喹
• 英文名: Piperaquine phosphate
• 中文别名: 1,3-双[4-(7-氯-喹啉-4-基)哌嗪-1-基]丙烷四磷酸盐四水合物; 1,3-双(4-(7-氯喹醇IN-4-基)哌嗪-1-基)丙烷; 磷酸哌奎; 1,3-双[4-(7-氯喹啉-4-基)哌嗪-1-基]丙烷
• 英文别名: 4,4'-(propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline); Piperaquine tetraphosphate tetrahydrate; 7-Chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline; Piperaquine phosphate 2000; 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline; Piperaquine; PiperaquineQ: What is Piperaquine Q: What is the CAS Number of Piperaquine; piperaquinoline; PIRERAQUINE PHOSPHATE; 7-chloro-4-[4-[3-[4-(7-chloro-4-quinolinyl)-1-piperazinyl]propyl]-1-piperazinyl]quinoline; 4,4'-(1,3-Propanediyldi-4; 4,4'-[1,3-Propanediylbis(4,1-piperazinediyl)]bis(7-chloroquinoline); 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline); 4,4'-(1,3-Propanediyldi-4,1-piperazindiyl)bis(7-chloroquinoline) phosphate; Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro; Piperaquinoline //BP; 1,3-Bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propane; 1,3-bis[1-(7-chloro-4-quinolyl)-4'-piperazinyl]propane tetraphosphate tetrahydrate; 4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro-quinoline); pipieraquine phosphate; BULK DRUG: PIPERAQUINE PHOSPHATE (DMF ADE); 4,4'-(1,3-Propanediydi-4,1-piper-azinediyl)bis[7-chloroquinoline]; 7-chloro-4-[4-[3-[4-(7-chloro-4-quinolyl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 721.1±60.0 °C at 760 mmHg
• 熔点: 198-200°C (lit.)
• 分子式: C₂₉H₃₂Cl₂N₆
• 分子量: 535.511
• 闪点: 389.9±32.9 °C
• 精确质量: 534.206543
• PSA: 38.74000
• LogP: 5.15
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.664
• 储存条件: 室温

生物活性

• 描述: 哌喹是一种双喹啉抗疟剂。哌喹可与青蒿素联合用于抗疟研究[1][2]。
• 相关类别:
  研究领域 >> 感染
• 体内研究: 哌喹(10-90 mg/kg；单次静脉注射)在小鼠试验的所有剂量下均可降低寄生虫血症[1]。哌喹(90 mg/kg；单次静脉注射)在健康小鼠中分别表现出t1/2、表观清除率和表观分布体积,在疟疾感染小鼠中分别为17.8天、33.5 mg•h/L、1.55 L/h/kg和956 L/kg[1]。
• 参考文献:

  [1]. Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11.

  [2]. Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VC3280000 CHEMICAL NAME : Quinoline, 4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro- CAS REGISTRY NUMBER : 4085-31-8 BEILSTEIN REFERENCE NO. : 0905079 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C29-H32-Cl2-N6 MOLECULAR WEIGHT : 535.57 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1098 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,273,1986

安全

• 危害码 (欧洲): Xi
• 海关编码: 2942000000

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
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Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%