Name | Glycyl-L-glutamine monohydrate |
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Synonyms |
H-Gly-Gln-OH
Gly-l-Gln (2S)-5-amino-2-[(2-aminoacetyl)amino]-5-oxopentanoic acid (S)-2-(2-Aminoacetylamino)-4-carbamoylbutyric acid MFCD00077124 L-Glutamine, glycyl- (2S)-5-Amino-2-[(aminoacetyl)amino]-5-oxopentanoic acid ZV2YVQMV1Z &&L or S Form (S)-5-Amino-2-(2-aminoacetamido)-5-oxopentanoic acid Glycyl-L-glutamine |
Description | Glycyl-glutamine (Glycyl-L-glutamine), as a enzymatic cleavage product of β-endorphin, is apparently an endogenous antagonist of beta-endorphin(1-31) in several systems[1]. Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide over glutamine (Gln)[2]. |
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Related Catalog | |
In Vitro | Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide. Glycyl-glutamine (Glycyl-L-glutamine) has an advantage over free glutamine (Gln) as growth factors for cell culture during both autoclaving and storage[2]. |
In Vivo | Glycyl-glutamine (Glycyl-L-glutamine) (0.3, 0.6, 1.0 and 10.0 nM) can dose-dependently inhibit beta-End-(1-31)-induced hypotension in pentobarbital-anesthetized rats[1]. |
References |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 643.1±55.0 °C at 760 mmHg |
Melting Point | 194°C |
Molecular Formula | C7H13N3O4 |
Molecular Weight | 203.196 |
Flash Point | 342.7±31.5 °C |
Exact Mass | 203.090607 |
PSA | 144.74000 |
LogP | -2.50 |
Vapour Pressure | 0.0±4.1 mmHg at 25°C |
Index of Refraction | 1.538 |
Storage condition | 2-8°C |
Water Solubility | 154 g/L (20 ºC) |
Synonym:Glutamine (L)-, glycyl Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels. Exposure Limits CAS# 13115-71-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white Odor: none reported pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: > 194 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: >160 deg C Solubility in water: 154 g/l (20 c) Specific Gravity/Density: Not available. Molecular Formula: C7H13N3O4.H2O Molecular Weight: 221.22 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, strong oxidants. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Irritating and toxic fumes and gases. Hazardous Polymerization: Will not occur. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 13115-71-4 unlisted. LD50/LC50: Not available. Carcinogenicity: Glycyl-L-glutamine monohydrate - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 13115-71-4: 0 Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 13115-71-4 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 13115-71-4 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
Hazard Codes | Xi:Irritant; |
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Risk Phrases | R36/37/38 |
Safety Phrases | S23-S24/25-S37/39-S26 |
WGK Germany | - |
HS Code | 2924199090 |
~% 13115-71-4 |
Literature: Bulletin of the Chemical Society of Japan, , vol. 37, p. 200 - 203 |
~% 13115-71-4 |
Literature: Bulletin of the Chemical Society of Japan, , vol. 37, p. 200 - 203 |
~% 13115-71-4 |
Literature: Bulletin of the Chemical Society of Japan, , vol. 37, p. 200 - 203 |
~% 13115-71-4 |
Literature: Bulletin of the Chemical Society of Japan, , vol. 37, p. 200 - 203 |
~% 13115-71-4 |
Literature: Journal of Organic Chemistry, , vol. 26, p. 1847 - 1849 |
~% 13115-71-4 |
Literature: Organic Process Research and Development, , vol. 5, # 2 p. 132 - 135 |
~% 13115-71-4 |
Literature: Bulletin of the Chemical Society of Japan, , vol. 37, p. 200 - 203 |
Precursor 1 | |
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DownStream 0 |
HS Code | 2924199090 |
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Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |