β-Endorphin (30-31) (bovine, camel, mouse, ovine)

Modify Date: 2024-01-02 08:58:31

β-Endorphin (30-31) (bovine, camel, mouse, ovine) Structure
β-Endorphin (30-31) (bovine, camel, mouse, ovine) structure
Common Name β-Endorphin (30-31) (bovine, camel, mouse, ovine)
CAS Number 13115-71-4 Molecular Weight 203.196
Density 1.4±0.1 g/cm3 Boiling Point 643.1±55.0 °C at 760 mmHg
Molecular Formula C7H13N3O4 Melting Point 194°C
MSDS N/A Flash Point 342.7±31.5 °C

 Use of β-Endorphin (30-31) (bovine, camel, mouse, ovine)


Glycyl-glutamine (Glycyl-L-glutamine), as a enzymatic cleavage product of β-endorphin, is apparently an endogenous antagonist of beta-endorphin(1-31) in several systems[1]. Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide over glutamine (Gln)[2].

 Names

Name Glycyl-L-glutamine monohydrate
Synonym More Synonyms

  Biological Activity

Description Glycyl-glutamine (Glycyl-L-glutamine), as a enzymatic cleavage product of β-endorphin, is apparently an endogenous antagonist of beta-endorphin(1-31) in several systems[1]. Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide over glutamine (Gln)[2].
Related Catalog
In Vitro Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide. Glycyl-glutamine (Glycyl-L-glutamine) has an advantage over free glutamine (Gln)  as growth factors for cell culture during both autoclaving and storage[2].
In Vivo Glycyl-glutamine (Glycyl-L-glutamine) (0.3, 0.6, 1.0 and 10.0 nM) can dose-dependently inhibit beta-End-(1-31)-induced hypotension in pentobarbital-anesthetized rats[1].
References

[1]. Unal CB1, et al. Beta-endorphin-induced cardiorespiratory depression is inhibited by glycyl-L-glutamine, a dipeptide derived from beta-endorphin processing.J Pharmacol Exp Ther. 1994 Nov;271(2):952-8

[2]. Roth E, et al. Influence of two glutamine-containing dipeptides on growth of mammalian cells.In Vitro Cell Dev Biol. 1988 Jul;24(7):696-8.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 643.1±55.0 °C at 760 mmHg
Melting Point 194°C
Molecular Formula C7H13N3O4
Molecular Weight 203.196
Flash Point 342.7±31.5 °C
Exact Mass 203.090607
PSA 144.74000
LogP -2.50
Vapour Pressure 0.0±4.1 mmHg at 25°C
Index of Refraction 1.538
Storage condition 2-8°C
Water Solubility 154 g/L (20 ºC)

 MSDS

Name: Glycyl-L-glutamine monohydrate 99% Material Safety Data Sheet
Synonym: Glutamine (L)-, glycyl
CAS: 13115-71-4
Section 1 - Chemical Product MSDS Name:Glycyl-L-glutamine monohydrate 99% Material Safety Data Sheet
Synonym:Glutamine (L)-, glycyl

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
13115-71-4 Glycyl-L-glutamine monohydrate 99 unlisted
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits CAS# 13115-71-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: > 194 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: >160 deg C
Solubility in water: 154 g/l (20 c)
Specific Gravity/Density: Not available.
Molecular Formula: C7H13N3O4.H2O
Molecular Weight: 221.22

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Irritating and toxic fumes and gases.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 13115-71-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Glycyl-L-glutamine monohydrate - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 13115-71-4: 0
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 13115-71-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 13115-71-4 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S23-S24/25-S37/39-S26
WGK Germany -
HS Code 2924199090

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

H-Gly-Gln-OH
Gly-l-Gln
(2S)-5-amino-2-[(2-aminoacetyl)amino]-5-oxopentanoic acid
(S)-2-(2-Aminoacetylamino)-4-carbamoylbutyric acid
MFCD00077124
L-Glutamine, glycyl-
(2S)-5-Amino-2-[(aminoacetyl)amino]-5-oxopentanoic acid
ZV2YVQMV1Z &&L or S Form
(S)-5-Amino-2-(2-aminoacetamido)-5-oxopentanoic acid
Glycyl-L-glutamine
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