Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Hydroxyurea
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Hydroxyurea
Price: ￥348.0/100g ￥258.0/25g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Hydroxyurea (Cytodrox)
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: Hydroxyurea (Cytodrox)
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Hydroxyurea
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

127-07-1

127-07-1 structure

127-07-1 structure

Name: Hydroxyurea
Chemical Name: hydroxyurea
CAS Number: 127-07-1
Molecular Formula: CH₄N₂O₂
Molecular Weight: 76.055
Catalog: Biochemical Inhibitor Immune inhibitor
Create Date: 2018-02-05 08:00:00
Modify Date: 2024-01-01 17:46:32
Hydroxyurea is a cell apoptosis inducer that inhibitDNA synthesis through inhibition of ribonucleotide reductase.

Name	hydroxyurea
Synonyms	hydroxycarbamide HYDROXYUREA (HYDROXYCARBAMIDE) HYDROXYUREA 127-07-1 Hydroxyurea Droxia HYDROXYCARBAMIDE, BP STANDARD HYDROXYHARNSTOFF amino-hydroxamic acid Hydrea HYDROXYHARNSTOFF(HYDROXYUREA) 1-hydroxyure hydroxyl urea Hydroxy urea HYDROXYCARBAMIDE (HYDROXYUREA) MFCD00007943 Urea, N-hydroxy- Onco-carbide Oxyurea N-HYDROXYUREA EINECS 204-821-7 Litalir 1-Hydroxyurea Biosupressin hydroxyure

Description	Hydroxyurea is a cell apoptosis inducer that inhibitDNA synthesis through inhibition of ribonucleotide reductase.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Cancer
In Vitro	Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases[1]. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The Gγ: Aγ-globin mRNA is induced 0.30- to 8-fold in vitro[2]. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages[3].
In Vivo	Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice[4].
Animal Admin	Mice: To determine whether hydroxyurea would improve anemia and/or prevent or diminish the development of organ damage in the absence of HbF induction, hydroxyurea, at doses of 25 mg/kg, 50 mg/kg, and 100 mg/kg, or vehicle is administered five days per week to SCD mice[4].
References	[1]. Kovacic P, et al. Hydroxyurea (therapeutics and mechanism): metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications. Med Hypotheses. 2011 Jan;76(1):24-31. [2]. Watanapokasin Y, et al. In vivo and in vitro studies of fetal hemoglobin induction by hydroxyurea in beta-thalassemia/hemoglobin E patients. Exp Hematol. 2005 Dec;33(12):1486-92. [3]. Lori F, et al. Rationale for the use of hydroxyurea as an anti-human immunodeficiency virus drug. Clin Infect Dis. 2000 Jun;30 Suppl 2:S193-7. [4]. Lebensburger JD, et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica. 2010 Sep;95(9):1599-603.

Density	1.5±0.1 g/cm3
Boiling Point	222.1±23.0 °C at 760 mmHg
Melting Point	135-140 °C
Molecular Formula	CH₄N₂O₂
Molecular Weight	76.055
Flash Point	88.1±22.6 °C
Exact Mass	76.027275
PSA	75.35000
LogP	-1.80
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.501
Storage condition	2-8°C
Water Solubility	soluble

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H340-H361
Precautionary Statements	P201-P280-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R46;R61
Safety Phrases	S53-S36/37-S45
RIDADR	2811
WGK Germany	3
RTECS	YT4900000
Packaging Group	III
HS Code	2928000090

Precursor 9
126669-78-1 57-13-6 75-13-8 590-28-3
51-79-6 22509-74-6 2072-71-1 1118-02-1
13465-08-2
DownStream 10
2509-16-2 10068-07-2 104308-36-3 77094-88-3
77094-89-4 1750-43-2 2048-50-2 124-38-9
7664-41-7 57-13-6

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%