149759-96-6

149759-96-6 structure
149759-96-6 structure
  • Name: FTase Inhibitor I
  • Chemical Name: b 581
  • CAS Number: 149759-96-6
  • Molecular Formula: C22H38N4O3S2
  • Molecular Weight: 470.69
  • Catalog: Biochemical Amino acids and their derivatives Methionine derivatives
  • Create Date: 2018-12-17 20:05:06
  • Modify Date: 2024-01-02 21:12:43
  • Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)[1].

Name b 581
Synonyms (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylbutyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
B581
Description Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)[1].
Related Catalog
In Vitro Ftase inhibitor I (B581) inhibits the ability of only Ras-F-transformed cells, but not geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)- (or Raf-) transformed cells, to grow in soft agar[1].
References

[1]. A D Cox, et al. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J Biol Chem. 1994 Jul 29;269(30):19203-6.

Density 1.161g/cm3
Boiling Point 716.1ºC at 760mmHg
Molecular Formula C22H38N4O3S2
Molecular Weight 470.69
Flash Point 386.9ºC
Exact Mass 470.23900
PSA 180.58000
LogP 3.25410
Appearance solid | white
Vapour Pressure 1.6E-21mmHg at 25°C
Index of Refraction 1.566
Storage condition −20°C
Water Solubility H2O: soluble
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3