149759-96-6

149759-96-6 structure

Name: FTase Inhibitor I
Chemical Name: b 581
CAS Number: 149759-96-6
Molecular Formula: C₂₂H₃₈N₄O₃S₂
Molecular Weight: 470.69
Catalog: Biochemical Amino acids and their derivatives Methionine derivatives
Create Date: 2018-12-17 20:05:06
Modify Date: 2026-07-01 11:15:34
Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)[1].

Name	b 581
Synonyms	N-[2(S)-[2(R)-AMINO-3-MERCAPTOPROPYLAMINO]-3-METHYLBUTYL]-PHE-MET-OH H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OH H-Cys-Val-Phe-Met-OH N-[2(S)-(2(R)-2-Amino-3-mercaptopropylamino)-3-methylbutyl]-L-phenylalanyl-L-methionine trifluoroacetate salt FTASE INHIBITOR I H-CYS-(R)-VAL-(R)-PHE-MET-OH N-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-me CYS-((R))-VAL-((R))-PHE-MET N-[(S)-2-((R)-2-Amino-3-Mercapto-propylaMino)-3-Methyl-butyl]-Phe-Met-OH, B581 B581 B581 //BP N-[2(S)-(2(R)-2-AMINO-3-MERCAPTOPROPYLAMINO)-3-METHYLBUTYL]-L-PHENYLALANYL-L-METHIONINE (2S)-2-({(2S)-2-[((2S)-2-{[(2R)-2-amino-3-sulfanylpropyl]amino}-3-Methylbutyl)amino]-3-phenylpropanoyl}amino)-4-(Methylsulfanyl)butanoic acid (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylbutyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid N-[(S)-2-((R)-2-AMINO-3-MERCAPTO-PROPYLAMINO)-3-METHYL-BUTYL]-PHE-MET-OH L-Methionine, N-[(2S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylbutyl]-L-phenylalanyl N-[2(S)-[2(R)-AMINO-3-MERCAPTOPROPYLAMINO]-3-METHYL-BUTYL]-PHE-MET

Description	Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase
In Vitro	Ftase inhibitor I (B581) inhibits the ability of only Ras-F-transformed cells, but not geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)- (or Raf-) transformed cells, to grow in soft agar[1].
References	[1]. A D Cox, et al. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J Biol Chem. 1994 Jul 29;269(30):19203-6.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3