FTase Inhibitor I
FTase Inhibitor I structure
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Common Name | FTase Inhibitor I | ||
|---|---|---|---|---|
| CAS Number | 149759-96-6 | Molecular Weight | 470.69 | |
| Density | 1.161g/cm3 | Boiling Point | 716.1ºC at 760mmHg | |
| Molecular Formula | C22H38N4O3S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 386.9ºC | |
Use of FTase Inhibitor IFtase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)[1]. |
| Name | b 581 |
|---|---|
| Synonym | More Synonyms |
| Description | Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)[1]. |
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| Related Catalog | |
| In Vitro | Ftase inhibitor I (B581) inhibits the ability of only Ras-F-transformed cells, but not geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)- (or Raf-) transformed cells, to grow in soft agar[1]. |
| References |
| Density | 1.161g/cm3 |
|---|---|
| Boiling Point | 716.1ºC at 760mmHg |
| Molecular Formula | C22H38N4O3S2 |
| Molecular Weight | 470.69 |
| Flash Point | 386.9ºC |
| Exact Mass | 470.23900 |
| PSA | 180.58000 |
| LogP | 3.25410 |
| Appearance of Characters | solid | white |
| Vapour Pressure | 1.6E-21mmHg at 25°C |
| Index of Refraction | 1.566 |
| Storage condition | −20°C |
| Water Solubility | H2O: soluble |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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[Anti tumor activity of farnesyl transferase inhibitor].
Gan To Kagaku Ryoho. 24(2) , 145-55, (1997) Posttranslational farnesylation by farnesyltransferase (FTase) is critical for the function of ras oncogene product and FTase has attracted attention as the new target of anticancer agents. B956 and B... |
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Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.
Oncogene 18(35) , 4930-9, (1999) IL-2 deprivation triggers apoptosis in the murine T cell line TS1alphabeta, a process that can be blocked by overexpression of Bcl-2. Here we show that Bcl-2 and Ras proteins interact in mitochondria ... |
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Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.
J. Biol. Chem. 268(25) , 18415-8, (1993) The ras protooncogene is involved in regulation of cell growth. Mutations that activate the protein result in uncontrolled cell growth. Ras undergoes a series of posttranslational processing events, t... |
| (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylbutyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid |
| B581 |