Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: SP-5,6-DCI-CBIMPS
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120912-54-1

120912-54-1 structure

Name: Sp-5,6-Dichloro-cBIMPS
Chemical Name: sp-5,6-dci-cbimps
CAS Number: 120912-54-1
Molecular Formula: C₁₂H₁₀Cl₂N₂NaO₅PS
Molecular Weight: 419.15300
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK PKA
Create Date: 2016-03-26 00:33:07
Modify Date: 2026-07-04 12:16:12
Sp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U46619-induced activation of Rho, Gq and G12/G13 in platelets[1][2][3].

Name	sp-5,6-dci-cbimps
Synonyms	Sp-5,6-Dichloro-cBIMPS, cAMP-dendent protein kinase activator 1H-Benzimidazole, 5,6-dichloro-1-[3,5-O-[(S)-mercaptophosphinylidene]-β-D-ribofuranosyl] 5,6-DCL-CBIMPSASP-ISOMER 5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole-3μ,5μ-cyclic monophosphorothioate, Sp- isomer sodium salt SP-5,6-DCI-CBIMPS 5,6-Dichloro-1-B-D-ribofuranosylbenzimidazole-3'',5''-cyclic monophosphothioa 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole-3’,5’-monophosphorothioate 5,6-dichlorobenzimidazoleriboside-3’,5’-monophosphorothioate,sp-isomer(sp5,6-dcl-cbimps) SP-5,6-DICHLORO-1-BETA-D-RIBOFURANOSYLBENZIMIDAZOLE-3',5'-MONOPHOSPHOROTHIOATE Sp 5,6-DCl-cBIMPS 5,6-Dichloro-(1-β-D-ribofuranosyl) benzimidazole 3',5'-cyclic monophosphothioate, Sp-isomer sodium salt MFCD06795834 5,6-Dichloro-(1-b-D-ribofuranosyl) benzimidazole 3',5'-cyclic monophosphothioate, Sp-isomer sodium salt

Description	Sp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U46619-induced activation of Rho, Gq and G12/G13 in platelets[1][2][3].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Metabolic Disease
In Vitro	Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) 以剂量和时间依赖性方式刺激离体胰岛释放胰岛素[2]。 Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) 增加葡萄糖 (8.5 mM) 刺激的胰岛素释放[2]。 SSp-5,6-DCl-cBIMPS (100 µM; 20 min) 抑制野生型小鼠血小板中 U46619 诱导的 Rho 激活，并抑制 U46619 诱导的人血小板中 Gq 和 G12/G13 激活[3 ]。 Western Blot Analysis[3] Cell Line: Wild-type mice, Human platelets Concentration: 100 µM Incubation Time: 20 min Result: Strongly suppressed U46619-induced Rho activation in wild-type, and inhibited U46619-induced activation of both Gq and G12/G13.
References	[1]. Sandberg M, et al. Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochem J. 1991 Oct 15;279 ( Pt 2)(Pt 2):521-7. [2]. Laychock SG. Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphorothioate is a potent stimulus for insulin release. Endocr Res. 1993;19(2-3):113-22. [3]. Gratacap MP, et al. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem. 2001 Dec 21;276(51):47906-13.

Molecular Formula	C₁₂H₁₀Cl₂N₂NaO₅PS
Molecular Weight	419.15300
Exact Mass	417.93200
PSA	130.70000
LogP	3.32240

WGK Germany	3

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