Sp-5,6-Dichloro-cBIMPS
Modify Date: 2025-08-26 11:24:52
Sp-5,6-Dichloro-cBIMPS structure
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Common Name | Sp-5,6-Dichloro-cBIMPS | ||
|---|---|---|---|---|
| CAS Number | 120912-54-1 | Molecular Weight | 419.15300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H10Cl2N2NaO5PS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Sp-5,6-Dichloro-cBIMPSSp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U46619-induced activation of Rho, Gq and G12/G13 in platelets[1][2][3]. |
| Name | sp-5,6-dci-cbimps |
|---|---|
| Synonym | More Synonyms |
| Description | Sp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U46619-induced activation of Rho, Gq and G12/G13 in platelets[1][2][3]. |
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| Related Catalog | |
| In Vitro | Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) 以剂量和时间依赖性方式刺激离体胰岛释放胰岛素[2]。 Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) 增加葡萄糖 (8.5 mM) 刺激的胰岛素释放[2]。 SSp-5,6-DCl-cBIMPS (100 µM; 20 min) 抑制野生型小鼠血小板中 U46619 诱导的 Rho 激活，并抑制 U46619 诱导的人血小板中 Gq 和 G12/G13 激活[3 ]。 Western Blot Analysis[3] Cell Line: Wild-type mice, Human platelets Concentration: 100 µM Incubation Time: 20 min Result: Strongly suppressed U46619-induced Rho activation in wild-type, and inhibited U46619-induced activation of both Gq and G12/G13. |
| References |
| Molecular Formula | C12H10Cl2N2NaO5PS |
|---|---|
| Molecular Weight | 419.15300 |
| Exact Mass | 417.93200 |
| PSA | 130.70000 |
| LogP | 3.32240 |
| InChIKey | NCXQEYBSXYJLGP-SBTLNALPSA-N |
| SMILES | OC1OSPOC2C(O)C(n3cnc4cc(Cl)c(Cl)cc43)OC12 |
| WGK Germany | 3 |
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| Sp 5,6-DCl-cBIMPS |
| MFCD06795834 |
| 5,6-DCL-CBIMPSASP-ISOMER |
| 5,6-Dichloro-1-B-D-ribofuranosylbenzimidazole-3'',5''-cyclic monophosphothioa |