Sp-5,6-Dichloro-cBIMPS

Modify Date: 2025-08-26 11:24:52

Sp-5,6-Dichloro-cBIMPS Structure
Sp-5,6-Dichloro-cBIMPS structure
Common Name Sp-5,6-Dichloro-cBIMPS
CAS Number 120912-54-1 Molecular Weight 419.15300
Density N/A Boiling Point N/A
Molecular Formula C12H10Cl2N2NaO5PS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Sp-5,6-Dichloro-cBIMPS


Sp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U46619-induced activation of Rho, Gq and G12/G13 in platelets[1][2][3].

 Names

Name sp-5,6-dci-cbimps
Synonym More Synonyms

 Sp-5,6-Dichloro-cBIMPS Biological Activity

Description Sp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U46619-induced activation of Rho, Gq and G12/G13 in platelets[1][2][3].
Related Catalog
In Vitro Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) 以剂量和时间依赖性方式刺激离体胰岛释放胰岛素[2]。 Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) 增加葡萄糖 (8.5 mM) 刺激的胰岛素释放[2]。 SSp-5,6-DCl-cBIMPS (100 µM; 20 min) 抑制野生型小鼠血小板中 U46619 诱导的 Rho 激活,并抑制 U46619 诱导的人血小板中 Gq 和 G12/G13 激活[3 ]。 Western Blot Analysis[3] Cell Line: Wild-type mice, Human platelets Concentration: 100 µM Incubation Time: 20 min Result: Strongly suppressed U46619-induced Rho activation in wild-type, and inhibited U46619-induced activation of both Gq and G12/G13.
References

[1]. Sandberg M, et al. Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochem J. 1991 Oct 15;279 ( Pt 2)(Pt 2):521-7.  

[2]. Laychock SG. Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphorothioate is a potent stimulus for insulin release. Endocr Res. 1993;19(2-3):113-22.  

[3]. Gratacap MP, et al. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem. 2001 Dec 21;276(51):47906-13.  

 Chemical & Physical Properties

Molecular Formula C12H10Cl2N2NaO5PS
Molecular Weight 419.15300
Exact Mass 417.93200
PSA 130.70000
LogP 3.32240

 Safety Information

WGK Germany 3

 Synonyms

Sp 5,6-DCl-cBIMPS
MFCD06795834
5,6-DCL-CBIMPSASP-ISOMER
5,6-Dichloro-1-B-D-ribofuranosylbenzimidazole-3'',5''-cyclic monophosphothioa
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