65914-84-3

65914-84-3 structure

Name: 1-Stearoyl-2-arachidonoyl-sn-glycerol
Chemical Name: 1-stearoyl-2-arachidonoyl-sn-glycerol
CAS Number: 65914-84-3
Molecular Formula: C₄₁H₇₂O₅
Molecular Weight: 645.007
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2018-12-25 14:04:40
Modify Date: 2026-07-16 21:03:41
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity[1][2].

Name	1-stearoyl-2-arachidonoyl-sn-glycerol
Synonyms	1-O-HEXADECYL-2-O-ACHIDONOYL-SN-GLYCEROL (1-hydroxy-3-octadecanoyloxypropan-2-yl) icosa-5,8,11,14-tetraenoate (2S)-1-Hydroxy-3-(stearoyloxy)-2-propanyl (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate 18:0/20:4-DG 2-ACHIDONOYL-1-STEOYL-SN-GLYCEROL 1-OCTADECANOYL-2-[(CIS,CIS,CIS,CIS)-5,8,11,14-EICOSATETRAENOYL]-SN-GLYCEROL 2-O-arachidonoyl-1-O-stearoyl-sn-glycerol 1-Steoyl-2-achidonoyl-sn-glycerol - - Calbiochem 1-Stein-2-achidonin-sn-Glycerol 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol 1-stearoyl-2-arachidonyl-sn-glycerol 1-STEAROYL-2-ARACHIDONOYL-SN-GLYCEROL 1-Steoyl-2-achidonoyl-sn-glycerol 2-achidonoyl-1-steoyl-sn-glycerol, 1-Octadecanoyl-2-([cis,cis,cis,cis]-5,8,11,14-eicosatetraenoyl)-sn-glycerol 1-steoyl-2-achidonoylglycerol C18:0/C20:4,[CIS,CIS,CIS,CIS]-5,8,11,14 1-stearoyl-2-arachidonoylglycerol 2-ACHIDONOYL-1-STEOYL-SN-GLYCEROL, A MPOULE 18::4 DG (2S)-1-hydroxy-3-(stearoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate 1-stearoyl-2-arachidonyl glycerol MFCD00070361 5,8,11,14-Eicosatetraenoic acid, (1S)-1-(hydroxymethyl)-2-[(1-oxooctadecyl)oxy]ethyl ester, (5Z,8Z,11Z,14Z) 1-STEIN-2-ACHIDONIN 1-Hydroxy-3-(stearoyloxy)-2-propanyl (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate DG(18:0/20:4(5Z,8Z,11Z,14Z)/0:0)[iso2]

Description	1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKC[2]
In Vitro	1-Stearoyl-2-arachidonoyl-sn-glycerol (0.3-3 μM) augments nonselective cation channel (NSCC) activity in airway smooth muscle cells[1]. 1-Stearoyl-2-arachidonoyl-sn-glycerol (0-5 μM) exerts significantly stimulatory effects on activation of PKCα, PKCδ, PKCγ, PKCε and PKCβI[2].
References	[1]. Song T, et, al. Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1455-66. [2]. Madani S, et, al. Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C. FASEB J. 2001 Dec;15(14):2595-601. [3]. Glasmacher S, et, al. Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Adv Biol Regul. 2021 May;80:100808.

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