2646-35-7

2646-35-7 structure

Name: D-Sedoheptulose 7-phosphate
Chemical Name: sedoheptulose 7-phosphate
CAS Number: 2646-35-7
Molecular Formula: C₇H₁₅O₁₀P
Molecular Weight: 425.47300
Catalog: Research Areas Metabolic Disease
Create Date: 2017-06-10 09:59:00
Modify Date: 2024-01-06 13:33:03
D-Sedoheptulose 7-phosphate is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose 7-phosphate can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds [1].

Name	sedoheptulose 7-phosphate
Synonyms	Sedoheptulose-7-phosphate O7-phosphono-D-altro-[2]heptulose D-sedoheptulose-7-phosphate (2,3,4,5,7-pentahydroxy-6-oxo-heptoxy)phosphonic acid

Description	D-Sedoheptulose 7-phosphate is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose 7-phosphate can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds [1].
Related Catalog	Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	Sedoheptulose 7-phosphate can be converted to ADP-l-glycero-β-d-manno-heptose by SepB, SepL, and SepC, it involves in ADP-sugar in microbial natural product biosynthesis[1]. SepB is an S-7-P isomerase, SepL involves in the biosynthesis of heptoses of the core region of E. coli LPS, and they catalyze a four-reaction relay converting S-7-P into ADP-d-glycero-β-d-manno-heptose [1]. Septacidin and its analogs are potential anticancer and pain-relief agents[1]. Hygromycin B is an anthelmintic agent practically used in swine and poultry farming[1].
References	[1]. Tang W, et al. d-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B.Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2818-2823.