4550-72-5

4550-72-5 structure

Name: NSC 15364
Chemical Name: 1,3-bis(4-aminophenyl)urea
CAS Number: 4550-72-5
Molecular Formula: C₁₃H₁₄N₄O
Molecular Weight: 242.277
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-10-30 17:18:07
Modify Date: 2024-01-14 11:47:19
NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis[1].

Name	1,3-bis(4-aminophenyl)urea
Synonyms	1,3-Bis(p-aminophenyl)urea N,N'-Bis(4-aminophenyl)urea 1,3-bis-(4-aminophenyl)urea 1,3-Bis(4-aminophenyl)urea Urea, N,N'-bis(4-aminophenyl)- 4,4'-diaminodiphenylurea Carbanilide,4'-diamino NSC 15364

Description	NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease
In Vitro	Mitochondrial membrane protein voltage-dependent anion channel 1 (VDAC1) oligomerization represents a prime target for agents designed to modulate apoptosis[1].
References	[1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.

Density	1.4±0.1 g/cm3
Boiling Point	381.4±27.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₄N₄O
Molecular Weight	242.277
Flash Point	184.5±23.7 °C
Exact Mass	242.116760
PSA	93.17000
LogP	-0.50
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.785
Storage condition	-20℃

HS Code	2924299090

587-90-6

~96%

4550-72-5

Literature: Rodriguez, Fernando; Rozas, Isabel; Kaiser, Marcel; Brun, Reto; Nguyen, Binh; Wilson, W. David; Garcia, Rory Nelson; Dardonville, Christophe Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 909 - 923

57-13-6

106-50-3

~73%

4550-72-5

Literature: Khan, S. Rehman; Gilani; Inayat, Asma; Waheed, Shaheena Pakistan Journal of Scientific and Industrial Research, 2006 , vol. 49, # 5 p. 319 - 323

100-01-6

4550-72-5

Literature: Turner, William R.; Werbel, Leslie M. Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1728 - 1740

100-28-7

4550-72-5

Literature: Uno, Masaharu; Koma, Yosuke; Ban, Hyun Seung; Nakamura, Hiroyuki Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 16 p. 5169 - 5173

101593-33-3

4550-72-5

Literature: Schiff,H.; Ostrogovich Justus Liebigs Annalen der Chemie, 1896 , vol. 293, p. 374 Chemische Berichte, 1894 , vol. 27, p. 398

60-09-3

4550-72-5

Literature: Soloduschenkow et al. Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1957 , vol. 30, p. 1361,1365; engl.Ausg.S.1430,1432

540-24-9

4550-72-5

Literature: Schiff,H.; Ostrogovich Justus Liebigs Annalen der Chemie, 1896 , vol. 293, p. 374 Chemische Berichte, 1894 , vol. 27, p. 398

122-80-5

4550-72-5

Literature: Schiff,H.; Ostrogovich Justus Liebigs Annalen der Chemie, 1896 , vol. 293, p. 374 Chemische Berichte, 1894 , vol. 27, p. 398

Precursor 8
587-90-6 57-13-6 106-50-3 100-01-6
100-28-7 101593-33-3 60-09-3 122-80-5
DownStream 1
25849-26-7

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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