- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Palmitic acid
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- Purity: 98.0%
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- Contact: Yang
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Pregna-4,9(11)-diene-3,20-dione,21-(acetyloxy)-17-hydroxy-
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- Purity: 98.0%
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- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
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- Zhongshan Xingrui Chemical Co. , Ltd.
- China
- Product Name: Anecortave Acetate
- Price: ￥Inquiry/25kg
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Wang Jie
- Email: 3096638339@qq.com
7753-60-8
7753-60-8 structure
- Name: Anecortave Acetate
- Chemical Name: [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
- CAS Number: 7753-60-8
- Molecular Formula: C23H30O5
- Molecular Weight: 386.48100
- Catalog: Signaling Pathways Metabolic Enzyme/Protease PAI-1
- Create Date: 2018-09-01 17:43:01
- Modify Date: 2026-07-01 18:36:01
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Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].
| Name | [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate |
|---|---|
| Synonyms |
Hydrocortisone Acetate Impurity 5
Acetate Aneconazole 21-Acetoxy-17α-hydroxypregna-4,9-diene-3,20-dione Acetic Acid Anacdic anecortave acetate 3,20-Dioxopregna-4,9-diene-17α,21-diol 21-acetate Hydrocortisone Acetate Impurity 5 (Hydrocortisone Acetate Impurity E) 17-ALPHA-HYDROXY-3,20-DIOXOPREGNA-4,9-DIENE-21-YL ACETATE 17-alpha,21-dihydroxypregna-4,9-diene-3,20-dione21-acetate 21-Acetoxy-17-hydroxypregna-4,9-diene-3,20-dione Anecortave Acetate (H5) Pregna-4,9-diene-17-ol-3,20-dione-21-acetate 21-Acetoxy-17-hydroxy-pregna-4,9(11)-dien-3,20-dion Anecortave acetate 21-(Acetyloxy)-17-hydroxypregna-4,9-diene-3,20-dione delta-9(11)-Hydrocortisone Acetate (Anecortave Acetate) Retaane suspension Hydrocortisone ester 17-alpha,21-dihydroxypregna-4,9-diene-3,20-dione 21-acetate(H6) Hydrocortisone Aceate Impurity E 2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate Anecortave Acetate[H6] 21-acetoxy-17-hydroxy-pregna-4,9(11)-diene-3,20-dione 17-Hydroxypregna-4,9-dione-3,20-dione-21-Acetate （H6) 17-Hydroxypregna-4,9-diene-3,20-dione-21-acetate Pregna-4,9-diene-17α,21-diol-3,20-dione 21-acetate Anacorta acetate Retaane AL-3789 Hydrocortisone Acetate Impurity E ANECORTAVE ACETATE F0E2980.997MG/MG(AI) 3,20-Dioxopregna-4,9-diene-17,21-diol 21-acetate 2-((10S,13S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate Pregna-4,9-diene-3,20-dione, 21-(acetyloxy)-17-hydroxy Anecortave 17-α,21-dihydroxypregna-4,9-diene-3,20-dione 21-acetate Anechota acetate 21-Acetoxypregna- 4,9-dien-17α-ol-3,20-dione |
| Description | Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PAI-1[2] |
| In Vivo | Anecortave acetate (5 μl of a 10% suspension; Injected into eyes) significantly inhibits pathologic retinal angiogenesis and increases PAI-1 mRNA levels[2]. Animal Model: Sprague-Dawley albino rats (intravitreally injected with premixed antibiotics to influence retinal vessel growth)[2] Dosage: 5 μl of a 10% suspension of Anecortave acetate Administration: Injected into eyes Result: significantly inhibited pathologic retinal angiogenesis in this model, while not significantly affecting normal intraretinal vessels. Increased 6-to-9-fold PAI-1 mRNA at 1 to 3 days after injection. |
| Density | 1.23g/cm3 |
|---|---|
| Boiling Point | 551.8ºC at 760 mmHg |
| Molecular Formula | C23H30O5 |
| Molecular Weight | 386.48100 |
| Flash Point | 188.4ºC |
| Exact Mass | 386.20900 |
| PSA | 80.67000 |
| LogP | 3.30170 |
| Index of Refraction | 1.572 |
| Precursor 8 | |
|---|---|
| DownStream 5 | |
![(8S,9R,10S,13S,14S,17R)-17-(2-acetoxyacetyl)-9-chloro-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl nicotinate structure](https://image.chemsrc.com/caspic/279/108674-98-2.png)
