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7753-60-8

7753-60-8 structure
7753-60-8 structure
  • Name: Anecortave Acetate
  • Chemical Name: [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
  • CAS Number: 7753-60-8
  • Molecular Formula: C23H30O5
  • Molecular Weight: 386.48100
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease PAI-1
  • Create Date: 2018-09-01 17:43:01
  • Modify Date: 2025-08-20 08:38:45
  • Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].

Name [2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Synonyms 2-((10S,13S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
21-Acetoxy-17-hydroxy-pregna-4,9(11)-dien-3,20-dion
Retaane
21-acetoxy-17-hydroxy-pregna-4,9(11)-diene-3,20-dione
AL-3789
2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Anecortave
Anecortave acetate
Retaane suspension
Description Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].
Related Catalog
Target

PAI-1[2]

In Vivo Anecortave acetate (5 μl of a 10% suspension; Injected into eyes) significantly inhibits pathologic retinal angiogenesis and increases PAI-1 mRNA levels[2]. Animal Model: Sprague-Dawley albino rats (intravitreally injected with premixed antibiotics to influence retinal vessel growth)[2] Dosage: 5 μl of a 10% suspension of Anecortave acetate Administration: Injected into eyes Result: significantly inhibited pathologic retinal angiogenesis in this model, while not significantly affecting normal intraretinal vessels. Increased 6-to-9-fold PAI-1 mRNA at 1 to 3 days after injection.
Density 1.23g/cm3
Boiling Point 551.8ºC at 760 mmHg
Molecular Formula C23H30O5
Molecular Weight 386.48100
Flash Point 188.4ºC
Exact Mass 386.20900
PSA 80.67000
LogP 3.30170
Index of Refraction 1.572
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