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127-31-1

127-31-1 structure
127-31-1 structure
Name fludrocortisone
Synonyms Fludrocortone
(11β)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione
9a-Fluorocortisol
9α-Fluorocortisol
Alflorone
Fluorocortisone
9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione
9a-Fluorohydrocortisone
Fludrocortisona [INN-Spanish]
Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β)-
MFCD00083333
9-α-Fluoro-17-hydroxycorticosterone
Fluohydrocortisone
(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Fluorocortisol
Florinef
9α-Fluoro-17-hydroxycorticosterone
9-Fluoro-11β,17,21-trihydroxypregn-4-ene-3,20-dione
Astonin-H
9α-Fludrocortisone
9a-Fluoro-17-hydroxycorticosterone
Fluohydrisone
(11b)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione
9-α-Fludrocortisone
EINECS 204-833-2
Fludrone
9α-Fluorohydrocortisone
fludrocortisone
Density 1.3±0.1 g/cm3
Boiling Point 564.7±50.0 °C at 760 mmHg
Melting Point 208-212ºC
Molecular Formula C21H29FO5
Molecular Weight 380.450
Flash Point 295.3±30.1 °C
Exact Mass 380.199890
PSA 94.83000
LogP 1.23
Vapour Pressure 0.0±3.5 mmHg at 25°C
Index of Refraction 1.584
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5025000
CHEMICAL NAME :
Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-
CAS REGISTRY NUMBER :
127-31-1
BEILSTEIN REFERENCE NO. :
3014278
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C21-H29-F-O5
MOLECULAR WEIGHT :
380.50
WISWESSER LINE NOTATION :
L E5 B666 OV MUTJ A1 BF CQ E1 FV1Q FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
8750 ug/kg
SEX/DURATION :
female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year: 102,347,1955
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 mg/kg
SEX/DURATION :
female 13-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 mg/kg
SEX/DURATION :
female 13-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973
Hazard Codes Xn
Risk Phrases 63
Safety Phrases 22-26-36
HS Code 2937210000
514-36-3 structure

514-36-3

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137
566-35-8 structure

566-35-8

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137
7753-60-8 structure

7753-60-8

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137
50733-54-5 structure

50733-54-5

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137
113862-93-4 structure

113862-93-4

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137
4383-30-6 structure

4383-30-6

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137
HS Code 2937210000
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