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127-31-1

127-31-1 structure

127-31-1 structure

Name: fludrocortisone
Chemical Name: fludrocortisone
CAS Number: 127-31-1
Molecular Formula: C₂₁H₂₉FO₅
Molecular Weight: 380.450
Catalog: API Hormone and endocrine-regulating drugs Adrenal corticosteroids
Create Date: 2018-07-14 17:21:02
Modify Date: 2026-07-07 18:12:36
Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.

Name	fludrocortisone
Synonyms	fludrocortone 9-fluoro-11beta,17,21-trihydroxy-pregn-4-ene-20-dione 9alpha-fluorocortisol 9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione 9-fluorohydrocortisone 9-fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione 9-FLUOROCORTISOL Fludrocortisona [INN-Spanish] florinef Fluohydrocortisone 9a-Fluoro-17-hydroxycorticosterone-d5 9α-Fluoro-17-hydroxycorticosterone 9alpha-fludrocortisone FLUDROCORTISONE-D6 (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one 9-Fluoro-11β,17,21-trihydroxypregn-4-ene-3,20-dione Astonin H-d5 9a-fluoro-17-hydroxycorticosterone fluohydrisone f-col 4-PREGNENE-9-ALPHA-FLUORO-11-BETA,17-ALPHA,21-TRIOL-3,20-DIONE 9a-Fluoro-17-hydroxycorticosterone, Fluohydrisone, Astonin H Fluohydrisone astonin-h Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β) fluorocortisol Fludrone fluohydrocortisone 9a-fluoro-11b,17a,21-trihydroxy-4-pregnene-3,20-dione fludrone Fludrocortone 9-fluoro-11-beta,17,21-trihydroxy-pregn-4-ene-20-dione 9-alpha-fluoro-17-hydroxycorticosterone Fludrocortisone //BP (11β)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione 9a-Fluorocortisol 9α-Fluorocortisol Alflorone FLUDROCORTISONE Fluorocortisone 4-Pregnene-9α-fluoro-11β,17α,21-triol-3,20-dione (11)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione Fludrocortisone Solution, 100ppm Fludrocotisone FLUOROCORTISONE NSC 11318-d5 4-PREGNEN-9ALPHA-FLUORO-11BETA, 17ALPHA, 21-TRIOL-3, 20-DIONE 4-PREGNEN-9-ALPHA-FLUORO-11-BETA, 17,21-TRIOL-3,20-DIONE 9a-Fluorohydrocortisone MFCD00083333 9-α-Fluoro-17-hydroxycorticosterone alflorone 9-alpha-fluorocortisol (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one 9-ALPHA-FLUOROHYDROCORTISONE (11)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione-d5 Fluorocortisol Florinef 9a-Fluorohydrocortisone-d5 Fluohydrisone-d5 Fludrocortisone-d2 17,21-trihydroxy-20-dion(11beta)-pregn-4-ene-9-fluoro-11 u5963 Fludrocortisone-d5 Astonin-H fludronef 9α-Fludrocortisone f-cortef (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one 9a-Fluoro-17-hydroxycorticosterone (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-17-glycoloyl-11,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one (11b)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione FludrocortisoneQ: What is Fludrocortisone Q: What is the CAS Number of Fludrocortisone Q: What is the storage condition of Fludrocortisone Q: What e the applications of Fludrocortisone 9alpha-fluoro-17-hydroxycorticosterone 9-α-Fludrocortisone EINECS 204-833-2 9-ALPHA-FLUORO-11-BETA,17-ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregn-4-ene-3,20-dione 9α-Fluorohydrocortisone

Description	Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor Research Areas >> Inflammation/Immunology
References	[1]. Jaal J, et al. Small Cell Lung Cancer Patient with Profound Hyponatremia and Acute Neurological Symptoms: An Effective Treatment with Fludrocortisone. Case Rep Oncol Med. 2015;2015:286029. [2]. Mori T, et al. Improved efficiency of hypervolemic therapy with inhibition of natriuresis by fludrocortisone in patients with aneurysmal subarachnoid hemorrhage. Journal of Neurosurgery [1999, 91(6):947-952]

Density	1.3±0.1 g/cm3
Boiling Point	564.7±50.0 °C at 760 mmHg
Melting Point	208-212ºC
Molecular Formula	C₂₁H₂₉FO₅
Molecular Weight	380.450
Flash Point	295.3±30.1 °C
Exact Mass	380.199890
PSA	94.83000
LogP	1.23
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.584
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5025000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-

CAS REGISTRY NUMBER :: 127-31-1

BEILSTEIN REFERENCE NO. :: 3014278

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H29-F-O5

MOLECULAR WEIGHT :: 380.50

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 BF CQ E1 FV1Q FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 8750 ug/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year: 102,347,1955

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 mg/kg

SEX/DURATION :: female 13-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 mg/kg

SEX/DURATION :: female 13-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973

Hazard Codes	Xn
Risk Phrases	63
Safety Phrases	22-26-36
HS Code	2937210000

514-36-3 structure

514-36-3

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137

566-35-8 structure

566-35-8

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137

7753-60-8 structure

7753-60-8

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137

50733-54-5 structure

50733-54-5

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137

113862-93-4 structure

113862-93-4

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137

4383-30-6 structure

4383-30-6

~%

127-31-1 structure

127-31-1

Literature: Journal of the American Chemical Society, , vol. 79, p. 1130,1137

Precursor 6
514-36-3 566-35-8 7753-60-8 50733-54-5
113862-93-4 4383-30-6
DownStream 2
338-95-4 337-02-0

HS Code	2937210000

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