105637-38-5

105637-38-5 structure

Name: Z-FA-FMK
Chemical Name: z-fa-fmk
CAS Number: 105637-38-5
Molecular Formula: C₂₁H₂₃FN₂O₄
Molecular Weight: 386.41700
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
Create Date: 2017-09-19 01:41:06
Modify Date: 2026-08-04 08:19:00
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position[1][2].

Name	z-fa-fmk
Synonyms	Z-PHE-ALA-FLUOROMETHYLKETONE (S,S)-Z-FA-FMK Cbamic acid, N-[(1S)-2-[[(1S)-3-fluoro-1-methyl-2-oxopropyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester Z-PHE-ALA-FMK (S)-2-(Cbz-amino)-N-[(S)-4-fluoro-3-oxo-2-butyl]-3-phenylpropanamide CASPASE INHIBITOR, NEGATIVE CONTROL CATHSIN B, INHIBITOR I NEGATIVE CONTROL INHIBITOR FOR ICE PROTEASES Z-FA-FMK, Cysteine protease inhibitor Z-PHE-ALA-CH2F Caspase Inhibitor, Negative Control - - Calbiochem CATHSIN B, INHIBITOR Z-FA-FLUOROMETHYLKETONE

Description	(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
References	[1]. Koike S, et al. Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification. Int J Mol Sci. 2016;17(9):1567. Published 2016 Sep 16. [2]. Harrison JS, et al. The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts. Oncotarget. 2016;7(24):36447-36460.