145196-87-8
145196-87-8 structure
- Name: Iodophenpropit dihydrobromide
- Chemical Name: 3-(1H-Imidazol-4-yl)propyl N-[2-(4-iodophenyl)ethyl]carbamimidoth ioate dihydrobromide
- CAS Number: 145196-87-8
- Molecular Formula: C15H21Br2IN4S
- Molecular Weight: 576.13200
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2016-01-24 07:34:58
- Modify Date: 2024-01-08 10:25:06
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Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM)[1].
| Name | 3-(1H-Imidazol-4-yl)propyl N-[2-(4-iodophenyl)ethyl]carbamimidoth ioate dihydrobromide |
|---|---|
| Synonyms | L-BMAA hydrochloride |
| Description | Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM)[1]. |
|---|---|
| Related Catalog | |
| Target |
H3 Receptor:0.32 nM (Kd) |
| In Vitro | Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor[2]. Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC50 of 1.57±0.3 μM[3]. |
| In Vivo | Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits[4]. Animal Model: New Zealand adult healthy rabbits of either sex weighing 1.63±0.36 kg[4] Dosage: 1 μg/kg Administration: Administered through intramuscular (i.m.); b.i.d.; for 10 days Result: Could influence a detectable antibody response to SRBC. |
| References |
| Molecular Formula | C15H21Br2IN4S |
|---|---|
| Molecular Weight | 576.13200 |
| Exact Mass | 573.89000 |
| PSA | 89.86000 |
| LogP | 5.85400 |