1104546-89-5
1104546-89-5 structure
- Name: BYK204165
- Chemical Name: (4Z)-4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinoli nedione
- CAS Number: 1104546-89-5
- Molecular Formula: C15H12N2O2
- Molecular Weight: 252.26800
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
- Create Date: 2016-06-09 06:51:53
- Modify Date: 2025-08-21 19:12:29
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BYK204165 is a potent PARP inhibitor. BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05), and murine PARP-2 (mPARP-2) with a pIC50 of 5.38, respectively. BYK204165 displays 100-fold selectivity for PARP-1[1].
| Name | (4Z)-4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinoli nedione |
|---|---|
| Synonyms | 4-(1-methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinolin-1,3-dione |
| Description | BYK204165 is a potent PARP inhibitor. BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05), and murine PARP-2 (mPARP-2) with a pIC50 of 5.38, respectively. BYK204165 displays 100-fold selectivity for PARP-1[1]. |
|---|---|
| Related Catalog | |
| Target |
hPARP-1:7.35 (pIC50) mPARP-2:5.38 (pIC50) |
| In Vitro | In kinetic experiments with human PARP-1, BYK204165 exhibits potent and competitive inhibition of enzyme activity, yielding a pKi value of 7.05[1]. BYK204165 exhibits low potency of PARP inhibition in C4I cells (pIC50 of 5.75)[1]. |
| In Vivo | BYK204165 is not investigated in vivo because of its short half-time (t1/2) of 23 min measured at rat microsomes in vitro[1]. |
| References |
| Molecular Formula | C15H12N2O2 |
|---|---|
| Molecular Weight | 252.26800 |
| Exact Mass | 252.09000 |
| PSA | 54.59000 |
| LogP | 1.84610 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |