17375-63-2
17375-63-2 structure
- Name: BGC 20-761
- Chemical Name: 2-(5-Methoxy-2-phenyl-1H-indol-3-yl)-N,N-dimethylethanamine
- CAS Number: 17375-63-2
- Molecular Formula: C19H22N2O
- Molecular Weight: 294.39100
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2017-11-15 06:49:23
- Modify Date: 2024-01-09 08:58:40
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BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent[1].
| Name | 2-(5-Methoxy-2-phenyl-1H-indol-3-yl)-N,N-dimethylethanamine |
|---|---|
| Synonyms |
3-(2-Dimethylamino-aethyl)-indol-5-ol,Hydrogenoxalat
3-(2-dimethylamino-ethyl)-indol-5-ol,hydrogenoxalate Bufotenin Oxalate bufotenin monooxalate [2-(5-methoxy-2-phenyl-indol-3-yl)-ethyl]-dimethyl-amine 3-(2-(Dimethylamino)ethyl)indol-5-ol oxalate Indol-5-ol,oxalate N,N-dimethyl-2-(5-hydroxy-1H-indol-3-yl)ethylamine oxalate Bufotenin-bioxalat N,N-dimethyl-2-(5-methoxy-2-phenylindol-3-yl)ethylamine bufotenine monooxalate |
| Description | BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent[1]. |
|---|---|
| Related Catalog | |
| Target |
Human 5-HT6 Receptor:20 nM (Ki) Human 5-HT2A Receptor:69 nM (Ki) Human D2 Receptor:140 nM (Ki) |
| In Vitro | BGC20-761 has highly potent and selective 5-HT6 receptor antagonist activity; rat Ki values for other rats receptors: 5-HT2A (470 nM), 5-HT2C (675 nM), D2, D3, D4, DAT and SERT (>10,000 nM)[1]. |
| In Vivo | BGC20-761 enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. BGC20-761 (2.5 mg/kg, 5 mg/kg and 10 mg/kg; i.p.) alone has no effect on social recognition in young rats, however, at doses of 5 mg/kg and 10 mg/kg i.p, BGC20-761 dose-dependently reverses a deficit of social recognition induced by Scopolamine (0.4 mg/kg i.p.)[1]. Animal Model: Forty-two male 8-week-old Longe Evans rats and 12 male four-week-old SpragueeDawley rats[1] Dosage: 2.5 mg/kg, 5 mg/kg and 10 mg/kg Administration: Administered (i.p.) immediately after the training session for the social recognition test Result: Administered alone did not show any difference in social recognition as compared to saline treated control animals. However, 5 mg/kg and 10 mg/kg reversed a Scopolamine induced deficit in social recognition. |
| References |
| Molecular Formula | C19H22N2O |
|---|---|
| Molecular Weight | 294.39100 |
| Exact Mass | 294.17300 |
| PSA | 28.26000 |
| LogP | 3.94760 |