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760-78-1

760-78-1 structure
760-78-1 structure
Name 2-aminopentanoic acid
Synonyms DL-NORVALINE
α-DL-Aminopentanoic acid
DL-2-Aminovaleric Acid
2-Aminovaleric acid
MFCD00064420
DL-norVal-OH
DL-2-Aminopentanoic acid
(±)-2-Aminopentanoic acid
H-DL-Nva-OH
rac-norvaline
a-Aminovaleric Acid
2-Aminopentanoic acid
EINECS 212-082-7
APE
DL-α-Aminovaleric acid
Norvaline
Norvaline, DL-
NVA
UNII:V639KTF2SZ
Norvaline (VAN)
(±)-Norvaline
aminovaleric acid
Description DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro DL-Norvaline, a derivative of L-norvaline[1], L-norvaline is a non-competitive inhibitor of arginase[2].
Cell Assay A murine macrophage cell line (RAW264.7) is used throughout the study, RAW264.7 cells are induced by A. actinomycetemcomitans-lipopolysaccharide, cells are incubated with various concentrations of L-norvaline or DL-norvaline (0.01, 0.1, 1, 10 mM) and 10 μg of A. actinomycetemcomitans-lipopolysaccharide. In other experiments, cells are incubated with antimurine CD14 or antimurine toll-like receptor 2 and 4 antibody at room temperature for 1 h, washed three times, and then stimulated with 10 μg of A. actinomycetemcomitans-lipopolysaccharide. All experiments are repeated three times, each consisting of triplicate cultures[1].
References

[1]. Sosroseno W, et al. Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2006 Jun;21(3):145-50.

[2]. El-Bassossy HM, et al. Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production. Vascul Pharmacol. 2012 Nov-Dec;57(5-6):194-200.
Density 1.1±0.1 g/cm3
Boiling Point 222.9±23.0 °C at 760 mmHg
Melting Point ≥300 °C (dec.)
Molecular Formula C5H11NO2
Molecular Weight 117.146
Flash Point 88.6±22.6 °C
Exact Mass 117.078979
PSA 63.32000
LogP 0.38
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.464
Storage condition Store at RT.
Water Solubility 1 g/10 mL (18 ºC)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29224995
HS Code 29224995
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title: CAS No. 760-78-1 | Chemsrc address: https://m.chemsrc.com/en/baike/441327.html

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