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556-67-2

556-67-2 structure
556-67-2 structure
Name octamethylcyclotetrasiloxane
Synonyms EINECS 209-136-7
Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-
Octamethylcyclotetrasiloxane
MFCD00003269
2,2,4,4,6,6,8,8-Octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane
2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
Density 1.0±0.1 g/cm3
Boiling Point 175.0±0.0 °C at 760 mmHg
Melting Point 17-18 °C(lit.)
Molecular Formula C8H24O4Si4
Molecular Weight 296.616
Flash Point 63.2±23.0 °C
Exact Mass 296.075165
PSA 36.92000
LogP 2.87360
Vapour density 1 (vs air)
Vapour Pressure 1.6±0.3 mmHg at 25°C
Index of Refraction 1.423
Storage condition 2-8°C
Water Solubility INSOLUBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GZ4397000
CHEMICAL NAME :
Cyclotetrasiloxane, octamethyl-
CAS REGISTRY NUMBER :
556-67-2
BEILSTEIN REFERENCE NO. :
1787074
LAST UPDATED :
199712
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C8-H24-O4-Si4
MOLECULAR WEIGHT :
296.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1230,1986
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1230,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1540 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
48 gm/m3/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1770 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands Liver - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
794 uL/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 ppm/6H/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530406
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
697 ppm/6H/28D-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516677
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
697 ppm/6H/28D-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516677 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3232 No. of Facilities: 128 (estimated) No. of Industries: 8 No. of Occupations: 12 No. of Employees: 3383 (estimated) No. of Female Employees: 1689 (estimated)
Symbol GHS02 GHS08
GHS02, GHS08
Signal Word Warning
Hazard Statements H226-H361-H413
Precautionary Statements P281
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful
Risk Phrases R53;R62
Safety Phrases S36/37-S46-S51-S61
RIDADR UN 1993 3/PG 3
WGK Germany 1
RTECS GZ4397000
Packaging Group III
Hazard Class 3
1251164-88-1 structure

1251164-88-1

1251165-18-0 structure

1251165-18-0

~70%

1251156-08-7 structure

1251156-08-7

Literature: EXELIXIS, INC.; ANAND, Neel, Kumar; ARCALAS, Arlyn; BLAZEY, Charles, M.; BUHR, Chris, A.; CANNOY, Jonah; EPHSTEYN, Sergey; JOHNSON, Henry, William Beecroft; JOSHI, Anagha; KIM, Byung, Gyu; LEAHY, James, W.; LEE, Matthew, Sangyup; MA, Sunghoon; MAC, Morrison, B.; NUSS, John, M.; TAKEUCHI, Craig, Stacy; WANG, Longcheng; WANG, Yong Patent: WO2010/118208 A1, 2010 ; Location in patent: Page/Page column 250-251 ; WO 2010/118208 A1
118939-18-7 structure

118939-18-7

1251165-18-0 structure

1251165-18-0

~%

1251156-08-7 structure

1251156-08-7

Literature: Takeuchi, Craig S.; Kim, Byung Gyu; Blazey, Charles M.; Ma, Sunghoon; Johnson, Henry W. B.; Anand, Neel K.; Arcalas, Arlyn; Baik, Tae Gon; Buhr, Chris A.; Cannoy, Jonah; Epshteyn, Sergey; Joshi, Anagha; Lara, Katherine; Lee, Matthew S.; Wang, Longcheng; Leahy, James W.; Nuss, John M.; Aay, Naing; Aoyama, Ron; Foster, Paul; Lee, Jae; Lehoux, Isabelle; Munagala, Narsimha; Plonowski, Arthur; Rajan, Sharmila; Woolfrey, John; Yamaguchi, Kyoko; Lamb, Peter; Miller, Nicole Journal of Medicinal Chemistry, 2013 , vol. 56, # 6 p. 2218 - 2234
1251162-64-7 structure

1251162-64-7

~%

1251156-08-7 structure

1251156-08-7

Literature: Takeuchi, Craig S.; Kim, Byung Gyu; Blazey, Charles M.; Ma, Sunghoon; Johnson, Henry W. B.; Anand, Neel K.; Arcalas, Arlyn; Baik, Tae Gon; Buhr, Chris A.; Cannoy, Jonah; Epshteyn, Sergey; Joshi, Anagha; Lara, Katherine; Lee, Matthew S.; Wang, Longcheng; Leahy, James W.; Nuss, John M.; Aay, Naing; Aoyama, Ron; Foster, Paul; Lee, Jae; Lehoux, Isabelle; Munagala, Narsimha; Plonowski, Arthur; Rajan, Sharmila; Woolfrey, John; Yamaguchi, Kyoko; Lamb, Peter; Miller, Nicole Journal of Medicinal Chemistry, 2013 , vol. 56, # 6 p. 2218 - 2234
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