2244-11-3

2244-11-3 structure

Name: Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate
Chemical Name: Alloxan monohydrate
CAS Number: 2244-11-3
Molecular Formula: C₄H₄N₂O₅
Molecular Weight: 160.085
Catalog: Biochemical Carbohydrate Double sugar
Create Date: 2018-08-15 21:12:03
Modify Date: 2024-01-09 18:07:20
Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2].

Name	Alloxan monohydrate
Synonyms	Mesoxalylcarbamide monohydrate 2,4,5,6-Tetraoxohexahydropyrimidine hydrate MFCD00149399 2,4,5,6-Tetraoxypyrimidine 2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate alloxan hydrate 2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate (1:1) ALLOXAN MONOHYDRATE alloxane monohydrate 1,3-dihydropyrimidine-2,4,5,6-tetraone,hydrate 2,4,5,6(1H,3H)-Pyrimidinetetrone, hydrate (1:1) Alloxan-monohydrat 5,6-Dioxyuracil alloxane hydrate Alloxan,monohydrate Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate EINECS 251-501-8 Pyrimidine-2,4,5,6(1H,3H)-tetrone hydrate (1:1)

Description	Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
In Vitro	Alloxan hydrate inhibits the peptidase activities of the purified 26S and 20S proteasomes[1].
References	[1]. Zhou W, et al. Diabetogenic agent alloxan is a proteasome inhibitor. Biochem Biophys Res Commun. 2017;488(2):400-406. [2]. Munday R, et al. The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives. J Endocrinol. 1993;139(1):153-163.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,325,1985

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UW0492000
HS Code	29335995

Precursor 0
DownStream 2
76002-68-1 79828-16-3

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%