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2244-11-3

2244-11-3 structure
2244-11-3 structure
  • Name: Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate
  • Chemical Name: Alloxan monohydrate
  • CAS Number: 2244-11-3
  • Molecular Formula: C4H4N2O5
  • Molecular Weight: 160.085
  • Catalog: Biochemical Carbohydrate Double sugar
  • Create Date: 2018-08-15 21:12:03
  • Modify Date: 2025-08-23 14:55:14
  • Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2].
Name Alloxan monohydrate
Synonyms Mesoxalylcarbamide monohydrate
2,4,5,6-Tetraoxohexahydropyrimidine hydrate
MFCD00149399
2,4,5,6-Tetraoxypyrimidine
2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate
alloxan hydrate
2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate (1:1)
ALLOXAN MONOHYDRATE
alloxane monohydrate
1,3-dihydropyrimidine-2,4,5,6-tetraone,hydrate
2,4,5,6(1H,3H)-Pyrimidinetetrone, hydrate (1:1)
Alloxan-monohydrat
5,6-Dioxyuracil
alloxane hydrate
Alloxan,monohydrate
Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate
EINECS 251-501-8
Pyrimidine-2,4,5,6(1H,3H)-tetrone hydrate (1:1)
Description Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2].
Related Catalog
In Vitro Alloxan hydrate inhibits the peptidase activities of the purified 26S and 20S proteasomes[1].
References

[1]. Zhou W, et al. Diabetogenic agent alloxan is a proteasome inhibitor. Biochem Biophys Res Commun. 2017;488(2):400-406.

[2]. Munday R, et al. The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives. J Endocrinol. 1993;139(1):153-163.

Density 1.681g/cm3
Boiling Point 374.1ºC at 760 mmHg
Melting Point 255 °C (dec.)(lit.)
Molecular Formula C4H4N2O5
Molecular Weight 160.085
Flash Point 180ºC
Exact Mass 160.012024
PSA 115.73000
Vapour Pressure 8.59E-07mmHg at 25°C
Storage condition 2-8°C
Water Solubility H2O: may be hazy yellow

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UW0492000
CHEMICAL NAME :
2,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrate
CAS REGISTRY NUMBER :
2244-11-3
LAST UPDATED :
199603
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C4-H2-N2-O4.H2-O
MOLECULAR WEIGHT :
160.10
WISWESSER LINE NOTATION :
T6MVMVVVJ &QH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Endocrine - diabetes mellitus Endocrine - hyperglycemia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
65400 ug/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
60 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System

MUTATION DATA

TEST SYSTEM :
Insect - Drosophila melanogaster
DOSE/DURATION :
1 pph
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,325,1985
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302 + H312 + H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UW0492000
HS Code 29335995
Precursor  0

DownStream  2

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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title: CAS No. 2244-11-3 | Chemsrc address: https://m.chemsrc.com/en/baike/442717.html

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