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Product Name: guanethidine
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55-65-2

55-65-2 structure

Name: guanethidine
Chemical Name: guanethidine
CAS Number: 55-65-2
Molecular Formula: C₁₀H₂₂N₄
Molecular Weight: 198.30800
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-05-18 08:00:00
Modify Date: 2024-01-06 00:27:21
Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

Name	guanethidine
Synonyms	Guanethidinum Octadine GUANETHIDINE (2-<Octahydroazocinyl-(1)>-ethyl)-guanidin Oktadin [2-(hexahydro-1-(2H)-azocinyl)ethyl]guanidine Isobarin Sanotensin 2-[2-(azocan-1-yl)ethyl]guanidine Oktatenzin (2-azocan-1-yl-ethyl)-guanidine Ismelin Eutensol guanethedine Abapresin

Description	Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.
In Vitro	Ablation of sympathetic fibers is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro[1]. .
In Vivo	Guanethidine (30 mg/kg, s.c., 1 h) unaffected IL-18 hypernociception in TNFR1(-/-) mice as a sympathetic blocker[2]. . Animal Model: Wild-type (WT) Balb/c,TNFR1(-/-)and IFN-γ-γ(-/-) mice[2]. Dosage: 30 mg/kg Administration: Guanethidine (30 mg/kg, s.c., 1 h, diluted in saline) Result: Pre-treatment with guanethidine (sympathetic blocker) unaffected IL-18 hypernociception in TNFR1(-/-) mice.
References	[1]. P Dubový, etal. Local chemical sympathectomy of rat bone marrow and its effect on marrow cell composition. [2]. Waldiceu A.VerriJr, etal. Antigen-induced inflammatory mechanical hypernociception in mice is mediated by IL-18. Brain Beha

Density	1.13g/cm3
Boiling Point	345.6ºC at 760mmHg
Molecular Formula	C₁₀H₂₂N₄
Molecular Weight	198.30800
Flash Point	162.8ºC
Exact Mass	198.18400
PSA	65.14000
LogP	1.86440
Index of Refraction	1.4910 (estimate)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF2975000

CHEMICAL NAME :: Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-

CAS REGISTRY NUMBER :: 55-65-2

LAST UPDATED :: 199606

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H22-N4

MOLECULAR WEIGHT :: 198.36

WISWESSER LINE NOTATION :: T8NTJ A2MYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,1671,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 845 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3856778

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,185,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 224 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3856778

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,349,1981

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,112,1973

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,112,1973

1126-67-6

1184-90-3

55-65-2

Literature: US4656291 A1, ;

Precursor 2
1126-67-6 1184-90-3
DownStream 0

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