62568-57-4

62568-57-4 structure

Name: Delta-Sleep Inducing Peptide trifluoroacetate salt
Chemical Name: dsip
CAS Number: 62568-57-4
Molecular Formula: C₃₅H₄₈N₁₀O₁₅
Molecular Weight: 848.814
Catalog: Biochemical Peptide
Create Date: 2018-09-10 17:41:18
Modify Date: 2024-01-09 22:50:13
δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties.

Name	dsip
Synonyms	trp-ala-gly-gly-asp-ala-ser-gly-glu UNII:YN28Z5YZ73 trp-ala-gly-gly-asn-ala-ser-gly-glu sleep inducing peptide L-Tryptophyl-L-alanylglycylglycyl-L-a-aspartyl-L-alanyl-L-serylglycyl-L-glutamic Acid L-Glutamic acid, L-tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-L-serylglycyl- emideltide L-Tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-L-serylglycyl-L-glutamic acid N-(N-(N-(N-(N-(N-(N-(N-L-Tryptophyl-L-alanyl)glycyl)glycyl)-L-a-aspartyl)-L-alanyl)-L-seryl)-glycyl)-L-glutamic Acid waggdasge TRP-ALA-GLY-GLY-ASP-ALA-SER: PO3H2-GLY-GLU [WAGGDA-S: PO3H2-GE] δ-Sleep Inducing Peptide

Description	δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Neurological Disease
In Vivo	In rabbit infused with δ-Sleep Inducing Peptide (DSIP), the spindle activity is increased, and heart and respiration rate are moderately decreased. δ-Sleep Inducing Peptide (DSIP) may act as a programming modulator at supra-operational level rather than as a transmitter at operational level[1]. δ-Sleep Inducing Peptide (DSIP; 40 μg/kg, i.p.) increases catalase and superoxide dismutase (SOD) activities and malonic dialdehyde (MDA) concentration in the liver homogenate of rats subjected to acute stress, but the opposite effects are observed at 120, and 360 μg/kg[2].
Animal Admin	Rats[2] Experiments are performed on male Wistar rats (n = 100) weighing 250-280 g. The animals are divided into groups (10 specimens per group). They are maintained under standard vivarium conditions and have free access to water and food (12:12-h light/dark regimen). δ-Sleep Inducing Peptide is dissolved in physiological saline and injected intraperitoneally 60 min before each stress exposure. Control animals receive an equivalent volume of physiological saline (1 mL/kg). The liver is homogenized in ice-cold physiological saline and centrifuged. The content of LPO products and activities of antioxidant enzymes are measured in the supernatant. LPO intensity is evaluated by malonic dialdehyde (MDA) concentration. Activities of superoxide dismutase (SOD) and catalase are measured spectrophotometrically. The total antioxidant activity (TAA) is evaluated by the method based on inhibition of ascorbate-induced and iron-induced oxidation of Tween-80 to MDA. The assay is conducted on a BTS-330 biochemical analyzer[2].
References	[1]. Monnier M, et al. The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide. Experientia. 1977 Apr 15;33(4):548-52. [2]. Bobyntsev II, et al. Effect of Delta Sleep-Inducing Peptide on Functional State of Hepatocytes in Rats During Restraint Stress. Bull Exp Biol Med. 2016 Feb;160(4):421-4.

Density	1.5±0.1 g/cm3
Boiling Point	1522.7±65.0 °C at 760 mmHg
Molecular Formula	C₃₅H₄₈N₁₀O₁₅
Molecular Weight	848.814
Flash Point	874.7±34.3 °C
Exact Mass	848.330078
PSA	406.74000
LogP	-3.57
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.612
Storage condition	−20°C
Water Solubility	Soluble in water at 0.5mg/ml

Safety Phrases	22-24/25
WGK Germany	3

130738-28-2

62568-57-4

Literature: Synthesis, , # 9 p. 845 - 846

4530-20-5

35661-39-3

71989-33-8

71989-14-5

71989-18-9

Detail

Literature: Russian Journal of Bioorganic Chemistry, , vol. 40, # 1 p. 1 - 8 Bioorg. Khim., , vol. 40, # 1 p. 3 - 11,9

Precursor 6
4530-20-5 35661-39-3 71989-33-8 71989-14-5
71989-18-9 13139-14-5
DownStream 4
56-41-7 56-45-1 56-86-0 56-40-6

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