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62568-57-4

62568-57-4 structure
62568-57-4 structure
  • Name: Delta-Sleep Inducing Peptide trifluoroacetate salt
  • Chemical Name: dsip
  • CAS Number: 62568-57-4
  • Molecular Formula: C35H48N10O15
  • Molecular Weight: 848.814
  • Catalog: Biochemical Peptide
  • Create Date: 2018-09-10 17:41:18
  • Modify Date: 2024-01-09 22:50:13
  • δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties.
Name dsip
Synonyms trp-ala-gly-gly-asp-ala-ser-gly-glu
UNII:YN28Z5YZ73
trp-ala-gly-gly-asn-ala-ser-gly-glu
sleep inducing peptide
L-Tryptophyl-L-alanylglycylglycyl-L-a-aspartyl-L-alanyl-L-serylglycyl-L-glutamic Acid
L-Glutamic acid, L-tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-L-serylglycyl-
emideltide
L-Tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-L-serylglycyl-L-glutamic acid
N-(N-(N-(N-(N-(N-(N-(N-L-Tryptophyl-L-alanyl)glycyl)glycyl)-L-a-aspartyl)-L-alanyl)-L-seryl)-glycyl)-L-glutamic Acid
waggdasge
TRP-ALA-GLY-GLY-ASP-ALA-SER: PO3H2-GLY-GLU [WAGGDA-S: PO3H2-GE]
δ-Sleep Inducing Peptide
Description δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties.
Related Catalog
In Vivo In rabbit infused with δ-Sleep Inducing Peptide (DSIP), the spindle activity is increased, and heart and respiration rate are moderately decreased. δ-Sleep Inducing Peptide (DSIP) may act as a programming modulator at supra-operational level rather than as a transmitter at operational level[1]. δ-Sleep Inducing Peptide (DSIP; 40 μg/kg, i.p.) increases catalase and superoxide dismutase (SOD) activities and malonic dialdehyde (MDA) concentration in the liver homogenate of rats subjected to acute stress, but the opposite effects are observed at 120, and 360 μg/kg[2].
Animal Admin Rats[2] Experiments are performed on male Wistar rats (n = 100) weighing 250-280 g. The animals are divided into groups (10 specimens per group). They are maintained under standard vivarium conditions and have free access to water and food (12:12-h light/dark regimen). δ-Sleep Inducing Peptide is dissolved in physiological saline and injected intraperitoneally 60 min before each stress exposure. Control animals receive an equivalent volume of physiological saline (1 mL/kg). The liver is homogenized in ice-cold physiological saline and centrifuged. The content of LPO products and activities of antioxidant enzymes are measured in the supernatant. LPO intensity is evaluated by malonic dialdehyde (MDA) concentration. Activities of superoxide dismutase (SOD) and catalase are measured spectrophotometrically. The total antioxidant activity (TAA) is evaluated by the method based on inhibition of ascorbate-induced and iron-induced oxidation of Tween-80 to MDA. The assay is conducted on a BTS-330 biochemical analyzer[2].
References

[1]. Monnier M, et al. The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide. Experientia. 1977 Apr 15;33(4):548-52.

[2]. Bobyntsev II, et al. Effect of Delta Sleep-Inducing Peptide on Functional State of Hepatocytes in Rats During Restraint Stress. Bull Exp Biol Med. 2016 Feb;160(4):421-4.
Density 1.5±0.1 g/cm3
Boiling Point 1522.7±65.0 °C at 760 mmHg
Molecular Formula C35H48N10O15
Molecular Weight 848.814
Flash Point 874.7±34.3 °C
Exact Mass 848.330078
PSA 406.74000
LogP -3.57
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.612
Storage condition −20°C
Water Solubility Soluble in water at 0.5mg/ml
Safety Phrases 22-24/25
WGK Germany 3
130738-28-2 structure

130738-28-2

~%

62568-57-4 structure

62568-57-4

Literature: Synthesis, , # 9 p. 845 - 846
4530-20-5 structure

4530-20-5

35661-39-3 structure

35661-39-3

71989-33-8 structure

71989-33-8

71989-14-5 structure

71989-14-5

71989-18-9 structure

71989-18-9

Detail
Literature: Russian Journal of Bioorganic Chemistry, , vol. 40, # 1 p. 1 - 8 Bioorg. Khim., , vol. 40, # 1 p. 3 - 11,9

Chemsrc provides CAS#:62568-57-4 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 62568-57-4 | Chemsrc address: https://m.chemsrc.com/en/baike/444851.html

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