DC Chemicals Limited
China
Product Name: Splitomicin
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3H-NAPHTHO[2,1-B]PYRAN-3-ONE, 1,2-DIHYDRO-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

5690-03-9

5690-03-9 structure

Name: Splitomicin
Chemical Name: Splitomicin
CAS Number: 5690-03-9
Molecular Formula: C₁₃H₁₀O₂
Molecular Weight: 198.217
Catalog: Biochemical Inhibitor Epigenetics Sirtuin inhibitor
Create Date: 2018-12-24 20:19:16
Modify Date: 2024-01-14 17:34:28
Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD+-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM[1].

Name	Splitomicin
Synonyms	Splitomicin 1,2-dihydrobenzo[f]chromen-3-one 1,2-Dihydro-3H-benzo[f]chromen-3-one MFCD03792600 3H-Naphtho[2,1-b]pyran-3-one, 1,2-dihydro-

Description	Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD+-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	Sir2p:60 μM (IC50)
In Vivo	Splitomicin (80 mg/kg with an intraperitoneal injection every 24 h for 5 days, in mice) enhances tissue factor (TF) activity in the arterial vessel wall and accelerates carotid artery thrombus formation in a photochemical injury model[2]. Animal Model: C57BL/6 mice aged 12-14 weeks weighing on average 27 g[2] Dosage: 80 mg/kg Administration: Intraperitoneal injection every 24 h for 5 days Result: Increased TF activity in mouse carotid artery as compared with the controls.
References	[1]. Bedalov A, et al. Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15113-8. [2]. Breitenstein A, et al. Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. Cardiovasc Res. 2011 Feb 1;89(2):464-72.

Density	1.3±0.1 g/cm3
Boiling Point	383.6±17.0 °C at 760 mmHg
Melting Point	73-74.5℃
Molecular Formula	C₁₃H₁₀O₂
Molecular Weight	198.217
Flash Point	161.2±18.4 °C
Exact Mass	198.068085
PSA	26.30000
LogP	3.03
Appearance	solid
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.656
Storage condition	2-8°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2914399090

79-10-7

135-19-3

~87%

5690-03-9

Literature: National University Corporation Nagoya University; ISHIHARA, Kazuaki; UYANIK, Muhammet; YASUI, Takeshi Patent: EP2684863 A1, 2014 ; Location in patent: Paragraph 0106 ;

14233-73-9

5690-03-9

Literature: Journal of the American Chemical Society, , vol. 70, p. 2119

135-19-3

5690-03-9

Literature: Journal of the American Chemical Society, , vol. 70, p. 2119

4352-89-0

5690-03-9

Literature: Journal of Chemical Research, Miniprint, , # 11 p. 1175 - 1184

107-13-1

135-19-3

5690-03-9

Literature: Journal of Organic Chemistry, , vol. 20, p. 1282,1285

79-10-7

135-19-3

5690-03-9

759458-82-7

Literature: Angewandte Chemie - International Edition, , vol. 50, # 26 p. 5834 - 5838

14103-18-5

5690-03-9

Literature: US2005/79995 A1, ; Page/Page column 13 ;

10441-53-9

5690-03-9

Literature: Sb. Statei Obshch. Khim., , p. 610,613 Chem.Abstr., , p. 986 Journal of the American Chemical Society, , vol. 70, p. 2119

Precursor 6
79-10-7 135-19-3 10441-53-9 14233-73-9
4352-89-0 107-13-1
DownStream 2
4352-89-0 10441-53-9

HS Code	2914399090
Summary	2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%