DC Chemicals Limited
China
Product Name: IWR-1
Price: $300.0/100mg $600.0/250mg $1200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: IWR-1-endo
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

1127442-82-3

1127442-82-3 structure

1127442-82-3 structure

Name: IWR-1
Chemical Name: IWR-1-endo
CAS Number: 1127442-82-3
Molecular Formula: C₂₅H₁₉N₃O₃
Molecular Weight: 409.437
Catalog: Biochemical Inhibitor Stem Cells & Wnt Signaling Paths (Stem Cells & Wnt) Wnt/beta-catenin inhibitor
Create Date: 2017-03-23 03:24:27
Modify Date: 2024-01-08 21:54:55
IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.

Name	IWR-1-endo
Synonyms	4-[(1R,2S,6R,7S)-3,5-Dioxo-4-azatricyclo[5.2.1.0]dec-8-en-4-yl]-N-(8-quinolinyl)benzamide 4-[(1R,2S,6R,7S)-3,5-Dioxo-4-azatricyclo[5.2.1.0]dec-8-en-4-yl]-N-(quinolin-8-yl)benzamide Benzamide, 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl- IWR-1

Description	IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Cancer
Target	IC50: 180 nM (Wnt)
In Vitro	Both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects in vitro. IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly[1]. IWR-1 (10 μM) induces stabilization of β-catenin disruption complex. IWR-1 (10 μM) is added to the medium together with MIF, the size of cell colonies is extremely decreased, and that indicates the promoting effect of MIF on NSPC proliferation is inhibited by IWR-1 in any MIF concentration group. 2, 5 and 10 μM of IWR-1 significantly inhibits the proliferation of NSPC dose-dependently. IWR-1 inhibites the promoting effect of MIF on NSPC differentiation to neuron lineage[2]. IWR-1 treatment in the presence of maximal stimulatory dose of FSH (0.5 ng/mL) results in a dose dependent inhibition of the stimulatory effect of FSH with > 75% inhibition observed at the maximal inhibitory dose of IWR-1 (1 µM). IWR-1 treatment partially reverses the FSH-induced inhibition of granulosa cell CARTPT mRNA expression[3].
References	[1]. Lu J, et al. Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3825-7. [2]. Zhang X, et al. Macrophage migration inhibitory factor promotes proliferation and neuronal differentiation of neural stem/precursor cells through Wnt/β-catenin signal pathway. Int J Biol Sci. 2013 Nov 28;9(10):1108-20. [3]. Gupta PS, et al. Regulation and Regulatory Role of WNT Signaling in Potentiating FSH Action during Bovine Dominant Follicle Selection. PLoS One. 2014 Jun 17;9(6):e100201.

Density	1.4±0.1 g/cm3
Boiling Point	643.9±55.0 °C at 760 mmHg
Molecular Formula	C₂₅H₁₉N₃O₃
Molecular Weight	409.437
Flash Point	343.2±31.5 °C
Exact Mass	409.142639
PSA	79.37000
LogP	2.65
Appearance	white to beige
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.741
Storage condition	Store at RT
Water Solubility	DMSO: soluble5mg/mL, clear