916482-17-2
916482-17-2 structure
- Name: YS121
- Chemical Name: 2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoic acid
- CAS Number: 916482-17-2
- Molecular Formula: C20H26ClN3O2S
- Molecular Weight: 407.957
- Catalog: Signaling Pathways Immunology/Inflammation PGE synthase
- Create Date: 2016-03-20 00:01:05
- Modify Date: 2025-08-25 18:45:26
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YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC50=12 μM in IL-1β-stimulated A549 cells[1].
| Name | 2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoic acid |
|---|---|
| Synonyms |
Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
YS121 Pirinixic acid-based compound,6a 2-({4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl}sulfanyl)octanoic acid |
| Description | YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC50=12 μM in IL-1β-stimulated A549 cells[1]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 557.4±50.0 °C at 760 mmHg |
| Molecular Formula | C20H26ClN3O2S |
| Molecular Weight | 407.957 |
| Flash Point | 290.9±30.1 °C |
| Exact Mass | 407.143433 |
| PSA | 100.41000 |
| LogP | 7.93 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.601 |
