YS121

Modify Date: 2024-01-05 10:20:54

YS121 Structure
YS121 structure
Common Name YS121
CAS Number 916482-17-2 Molecular Weight 407.957
Density 1.3±0.1 g/cm3 Boiling Point 557.4±50.0 °C at 760 mmHg
Molecular Formula C20H26ClN3O2S Melting Point N/A
MSDS N/A Flash Point 290.9±30.1 °C

 Use of YS121


YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC50=12 μM in IL-1β-stimulated A549 cells[1].

 Names

Name 2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoic acid
Synonym More Synonyms

 YS121 Biological Activity

Description YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC50=12 μM in IL-1β-stimulated A549 cells[1].
Related Catalog
References

[1]. Hui-Hua Chang, et al. Identification and development of mPGES-1 inhibitors: where we are at?. Future Med Chem. 2011 Nov;3(15):1909-34.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 557.4±50.0 °C at 760 mmHg
Molecular Formula C20H26ClN3O2S
Molecular Weight 407.957
Flash Point 290.9±30.1 °C
Exact Mass 407.143433
PSA 100.41000
LogP 7.93
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.601

 Synonyms

Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
YS121
Pirinixic acid-based compound,6a
2-({4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl}sulfanyl)octanoic acid