1018340-07-2

1018340-07-2 structure

Name: CAY10581
Chemical Name: cay10581
CAS Number: 1018340-07-2
Molecular Formula: C₂₂H₂₁NO₄
Molecular Weight: 363.406
Catalog: Signaling Pathways Metabolic Enzyme/Protease Indoleamine 2,3-Dioxygenase (IDO)
Create Date: 2018-06-15 10:07:05
Modify Date: 2024-01-30 17:20:46
CAY10581, a pyranonaphthoquinone derivative, is a highly specific and reversible uncompetitive IDO Inhibitor with an IC50 of 55 nM[1][2].

Name	cay10581
Synonyms	2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3S,4S)- (3S,4S)-4-(Benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Description	CAY10581, a pyranonaphthoquinone derivative, is a highly specific and reversible uncompetitive IDO Inhibitor with an IC50 of 55 nM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Target	IDO:55 nM (IC50)
In Vitro	CAY10581 (100 nM; 24 小时) 消除 IFN-γ 在 MSCs 中的生长抑制[1]。 CAY10581 (化合物 36) 在 100 μM 浓度下 24 小时后对 T-REx 细胞活力的影响极小[2]。 Cell Viability Assay[1] Cell Line: Mesenchymal stem cells (MSCs) Concentration: 100 nM Incubation Time: 24 h post-treatment Result: Abrogated the growth inhibition by IFN-gamma (50 ng/ml) in MSCs.
References	[1]. Sanjeev Kumar, et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. [2]. Siddaraju V Boregowda, et al. A Clinical Indications Prediction Scale Based on TWIST1 for Human Mesenchymal Stem Cells. EBioMedicine. 2015 Dec 24;4:62-73.