Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (-)-Polygodial
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Polygodial
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

6754-20-7

6754-20-7 structure

6754-20-7 structure

Name: (-)-Polygodial
Chemical Name: polygodial
CAS Number: 6754-20-7
Molecular Formula: C₁₅H₂₂O₂
Molecular Weight: 234.334
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2018-07-04 18:11:42
Modify Date: 2024-01-02 18:58:37
Polygodial (Poligodial) is an antifungal potentiator[1]. Polygodial is a sesquiterpene with anti-hyperalgesic properties[2].

Name	polygodial
Synonyms	(1R,4aS,8aS)-5,5,8a-trimethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-1,2-dicarbaldehyde UNII:A00RAV0W57 Podofilox Wartec Condylox Podophyllotoxin 7 1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)- Condyline [1R-(1a,4ab,8aa)]-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde S-Isopropylisothiourea hydrobromide Polygodial Warticon (1R,4aS,8aS)-5,5,8a-Trimethyl-1,4,4a,5,6,7,8,8a-octahydro-1,2-naphthalenedicarbaldehyde Podophyllinic acid lactone

Description	Polygodial (Poligodial) is an antifungal potentiator[1]. Polygodial is a sesquiterpene with anti-hyperalgesic properties[2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Inflammation/Immunology
In Vitro	Polygodial exhibits fungicidal activity against Saccharomyces cerevisiae, Candida albicans, and other fungal pathogens in standardized susceptibility tests (NCCLS). Polygodial (12.5 μg/mL, 3 hours) induces significant shrinkage compared to controls in Saccharomyces cerevisiae cells with the minimum fungicidal concentration (MFC) for 106 CFU/mL in RPMI 1640 medium[3]. Cell Viability Assay[3] Cell Line: S. cerevisiae cells Concentration: 12.5 μg/mL Incubation Time: 3 hours Result: Treated cells exhibited significant shrinkage compared to controls, and the organization of subcellular organelles appears either disrupted or compacted.
In Vivo	Polygodial is a sesquiterpene isolated from the barks of Drymis winteri (Winteraceae). Polygodial (0.5 to 10 mg/kg; 0.5 h; given by i.p. route to mice) induces significant, dose-related and almost complete inhibition of Acetic acid, Kaolin and Zymosan-induced abdominal constrictions. The calculated mean ID50 values are 0.8, 2.1 and 2.6 mg/kg and maximal inhibitions of 90.0±3.0, 98.0±1.0 and 97.0±2.0 %, against Acetic acid, Kaolin and Zymosan, respectively. Polygodial is about 14- to 27-fold more potent than the hydroalcoholic extract (HE) at the ID50 level[2]. Animal Model: Non-fasted male Swiss mice (20-30 g) or male Wistar rats (150-180 g)[2] Dosage: 0.1 to 10 mg/kg Administration: Injected i.p. 0.5 h before the injection of irritant substances Result: Produced significant inhibition of Acetic acid, Kaolin and Zymosan-induced writhing in mice.
References	[1]. I Kubo, et al. Polygodial, an antifungal potentiator. J Nat Prod. Jan-Feb 1988;51(1):22-9. [2]. G L Mendes, et al. Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae). Life Sci. 1998;63(5):369-81. [3]. C S Lunde, et al. Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2000 Jul;44(7):1943-53.

Density	1.1±0.1 g/cm3
Boiling Point	330.7±35.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₂O₂
Molecular Weight	234.334
Flash Point	124.0±22.9 °C
Exact Mass	234.161987
PSA	34.14000
LogP	3.84
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.570
Storage condition	20°C

Hazard Codes	Xn
Risk Phrases	52/53
RIDADR	NONH for all modes of transport
RTECS	QJ2850000