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895542-09-3

895542-09-3 structure
895542-09-3 structure
  • Name: Trifarotene
  • Chemical Name: 4-[3-(3-tert-butyl-4-pyrrolidin-1-ylphenyl)-4-(2-hydroxyethoxy)phenyl]benzoic acid
  • CAS Number: 895542-09-3
  • Molecular Formula: C29H33NO4
  • Molecular Weight: 459.577
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
  • Create Date: 2018-08-29 16:37:34
  • Modify Date: 2024-01-04 07:48:14
  • Trifarotene is a retinoic acid receptor (RAR) agonist with Kdapp of 2, 15 and 500 nM for RARγ, RARβ and RARα, respectively.

Name 4-[3-(3-tert-butyl-4-pyrrolidin-1-ylphenyl)-4-(2-hydroxyethoxy)phenyl]benzoic acid
Synonyms 4'-(2-Hydroxyethoxy)-3''-(2-methyl-2-propanyl)-4''-(1-pyrrolidinyl)-1,1':3',1''-terphenyl-4-carboxylic acid
[1,1':3',1''-Terphenyl]-4-carboxylic acid, 3''-(1,1-dimethylethyl)-4'-(2-hydroxyethoxy)-4''-(1-pyrrolidinyl)-
Trifarotene
CD5789
UNII-0J8RN2W0HK
Description Trifarotene is a retinoic acid receptor (RAR) agonist with Kdapp of 2, 15 and 500 nM for RARγ, RARβ and RARα, respectively.
Related Catalog
Target

Kdapp: 2 nM (RARγ), 15 nM (RARβ), 500 nM (RARα)[1]

References

[1]. Thibaud Biadatti, et al. Novel ligands that modulate rar receptors, and use thereof in human medicine and in cosmetics. WO 2006066978 A1.

Density 1.2±0.1 g/cm3
Boiling Point 641.9±55.0 °C at 760 mmHg
Molecular Formula C29H33NO4
Molecular Weight 459.577
Flash Point 342.0±31.5 °C
Exact Mass 459.240967
PSA 70.00000
LogP 6.27
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.599
Storage condition 2-8℃