53330-02-2

53330-02-2 structure

Name: S-(N-PhenethylthiocarbaMoyl)-L-cysteine
Chemical Name: phenethyl isothiocyanate cysteine conjugate
CAS Number: 53330-02-2
Molecular Formula: C₁₂H₁₆N₂O₂S₂
Molecular Weight: 284.40
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2017-01-20 16:59:21
Modify Date: 2024-01-12 06:38:35
S-(N-PhenethylthiocarbaMoyl)-L-cysteine, a anticarcinogenic agent, has antileukaemic activity with a GC50 value of 336 nM. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells [1].

Name	phenethyl isothiocyanate cysteine conjugate
Synonyms	s-(n-methylthiocarbamoyl)-l-cysteine

Description	S-(N-PhenethylthiocarbaMoyl)-L-cysteine, a anticarcinogenic agent, has antileukaemic activity with a GC50 value of 336 nM. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits cell growth of HL60 cell, GC50=336 nM[1]. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells, IC50=6.47μM[1]. S-(N-PhenethylthiocarbaMoyl)-L-cysteine induced DNA fragmentation in HL 60 cells[1]. Cell Proliferation Assay[1] Cell Line: HL60 cells Concentration: 0.1-10 μM Incubation Time: 48 hours Result: Inhibited the cell growth with a GC50 value of 336 nM. Cell Proliferation Assay[1] Cell Line: HL60 cells Concentration: 4 μM Incubation Time: 0, 20, 40, 60, 80, 100 hours Result: Inhibited the cell growth.
References	[1]. [1] Adesida A, Edwards LG, Thornalley PJ. Inhibition of human leukaemia 60 cell growth by mercapturic acid metabolites of phenylethyl isothiocyanate. Food Chem Toxicol. 1996 Apr;34(4):385-92.

Hazard Codes	Xi

Precursor 0
DownStream 2
52-90-4 2257-09-2