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上海市上海市普陀区
产品名：Flupentixol
纯度：98.0%
规格：100mg/250mg/1g
联系人：小陈

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2709-56-0生产厂家

2709-56-0价格

2709-56-0

2709-56-0结构式

常用中文名：三氟噻吨
常用英文名：Flupentixol
CAS号：2709-56-0
分子式：C₂₃H₂₅F₃N₂OS
分子量：434.51800
相关类别：信号通路 G 蛋白偶联受体/G 蛋白多巴胺受体
发布时间：2018-08-01 14:37:24
更新时间：2026-06-30 18:51:19
氟哌噻醇是一种具有D1和D2多巴胺受体拮抗作用的高效硫黄嘌呤。氟哌替索用于治疗精神分裂症以及抗焦虑和抑郁障碍[1][2]。

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中文名	三氟噻吨
英文名	flupenthixol
中文别名	4-(3-(2-(三氟甲基)-9H-噻吨-9-亚基)丙基)-1-哌嗪乙醇
英文别名	flupenthixolQ: What is flupenthixol Q: What is the CAS Number of flupenthixol Q: What is the storage condition of flupenthixol Q: What e the applications of flupenthixol 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-1-piperazineethano flupenthixole Aids-115423 lc44 (alpha,beta)-flupenthixol Flupentiol siplil emergil 4-(3-(2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-1-piperazineethanol FLUPENTIOL Flupentixolum Flupentixol alcohol(Flupentixol impurity) Aids115423 2-trifluoromethyl-9-(3-(4-(beta-hydroxyethyl)-1-piperazinyl)propylidene)thio siplol 1-Piperazineethanol,4-[3-[2-(trifluoroMethyl)-9H-thioxanthen-9-ylidene]propyl] CIS(Z)-FLUPENTIXOL 2HCL 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-1-piperazineethanol 4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-1-piperazineethan 1-piperazineethanol,4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propy fluanxol fluxanxol siplarol siplaril flupentixol n7009 1-Piperazineethanol, 4-[(3Z)-3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl] 2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol [3H]-(Z)-Flupentixol

描述	氟哌噻醇是一种具有D1和D2多巴胺受体拮抗作用的高效硫黄嘌呤。氟哌替索用于治疗精神分裂症以及抗焦虑和抑郁障碍[1][2]。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体信号通路 >> 神经信号通路 >> 多巴胺受体研究领域 >> 神经疾病
靶点	D1 Receptor D2 Receptor
参考文献	[1]. Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71. [2]. Ruhrmann S, et al. Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1012-22.

密度	1.306g/cm3
沸点	554.7ºC at 760mmHg
分子式	C₂₃H₂₅F₃N₂OS
分子量	434.51800
闪点	289.3ºC
精确质量	434.16400
PSA	52.01000
LogP	4.47750
外观性状	白色或灰白色固体
折射率	1.607

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL9900000

CHEMICAL NAME :: 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl )-

CAS REGISTRY NUMBER :: 2709-56-0

LAST UPDATED :: 199507

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H25-F3-N2-O-S

MOLECULAR WEIGHT :: 434.56

WISWESSER LINE NOTATION :: T C666 BS IYJ IU3- AT6N DNTJ D2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 900 ug/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - changes in motor activity (specific assay) Behavioral - coma

REFERENCE :: DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 15,388,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 367 ug/kg/12D-I

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - muscle weakness Behavioral - headache

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,93,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2121,1977

危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R20/21/22
安全声明 (欧洲)	36/37/39
危险品运输编码	UN 2811 6.1/PG 3
WGK德国	3
RTECS号	TL9900000

103-76-4结构式

103-76-4

28973-34-4结构式

28973-34-4

~%

2709-56-0结构式

2709-56-0

53772-85-3结构式

53772-85-3

文献：LABORATORIO CHIMICO INTERNAZIONALE S.P.A. Patent: WO2005/37820 A1, 2005 ; Location in patent: Page/Page column 8-9 ;

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